YRC Public Data Repository - Protein Structure Prediction

Protein:	Taf12-PB, Taf12-PA
Organism:	Drosophila melanogaster
Length:	196 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Taf12-PB, Taf12-PA.

Description	E-value	Query Range	Subject Range
gi\|457003 - gi\|457003\|gb\|AAB29540.1\| dTAFII30 alpha; TFIID subunit [Drosophila sp.] gi\|542566, gi\|739458 - gi\|739458\|prf\|\|2003282A transcription factor IID:SUBUNIT=alpha, pir\|\|A49453 transcription initiation...	272.0	[0..1]	[196..1]
gi\|55778020 - gi\|55778020\|gb\|AAH50160.1\| Taf12 protein [Danio rerio]	219.0	[0..40]	[196..1]
FBpp0307200, Taf... - The gene TBP-associated factor 12 is referred to in FlyBase by the symbol Dmel\Taf12 (CG17358, FBgn0...	217.0	[0..37]	[196..1]
gi\|61370125, gi\|... - gi\|61370130\|gb\|AAX43442.1\| TAF12 RNA polymerase II TATA box binding protein-associated factor [synth...	216.0	[0..43]	[195..6]
gi\|123994127, gi... - gi\|61360319\|gb\|AAX41843.1\| TAF12 RNA polymerase II TATA box binding protein-associated factor [synth... TAF12 - TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa	215.0	[0..43]	[195..6]
TAF12_BOVIN - Transcription initiation factor TFIID subunit 12 OS=Bos taurus GN=TAF12 PE=2 SV=1	214.0	[0..43]	[195..6]
tr\|M3WQ01\|M3WQ01... - TATA-box binding protein associated factor 12 OS=Felis catus GN=TAF12 PE=4 SV=1 ENSCJAT00000018889 - null gi\|109000147, gi... - gi\|109000150\|ref\|XP_001113189.1\| PREDICTED: TAF12 RNA polymerase II, TATA box binding protein (TBP)-... tr\|G3H1Y6\|G3H1Y6... - Transcription initiation factor TFIID subunit 12 OS=Cricetulus griseus GN=I79_004179 PE=4 SV=1 gi\|114555130, gi... - gi\|114555130\|ref\|XP_513257.2\| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes], gi\|114555... gi\|73950083, gi\|... - gi\|73966013\|ref\|XP_851093.1\| PREDICTED: similar to Transcription initiation factor TFIID subunit 12 ... CCDS326.1_1 - null	213.0	[0..43]	[195..6]
TAF12_MOUSE - Transcription initiation factor TFIID subunit 12 OS=Mus musculus GN=Taf12 PE=1 SV=1	211.0	[0..43]	[195..6]

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Predicted Domain #1

Region A:
Residues: [1-88]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLFTTFDS NGVAEHHLHH NHNSTSSASG LLHDPPMASP SQHSPMTNNS NSSSQNGGPV  60
   61 SGLGTGTGPI SGGSKSSNHT SSAAGSEN

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.18
Match:	2es4D
Description:	Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [89-196]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPMLTKPRLT ELVREVDTTT QLDEDVEELL LQIIDDFVED TVKSTSAFAK HRKSNKIEVR  60
   61 DVQLHFERKY NMWIPGFGTD ELRPYKRAAV TEAHKQRLAL IRKTIKKY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.30103
Match:	1h3oB
Description:	TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	9.25279783093877	bayes_pls_golite062009
DNA binding	4.49118409263799	bayes_pls_golite062009
nucleic acid binding	4.35201412176948	bayes_pls_golite062009
transcription regulator activity	4.08606081850613	bayes_pls_golite062009
transcription initiation factor activity	3.96621818094279	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.28941584139552	bayes_pls_golite062009
binding	3.27510691458843	bayes_pls_golite062009
transcription factor activity	2.51581622888695	bayes_pls_golite062009
transcription activator activity	1.25487495162413	bayes_pls_golite062009
transcription factor binding	1.15204005455906	bayes_pls_golite062009
transcription coactivator activity	1.1297723528047	bayes_pls_golite062009
nucleotidyltransferase activity	1.10331930589736	bayes_pls_golite062009
protein binding	1.07873333188144	bayes_pls_golite062009
transcription cofactor activity	1.01502031330902	bayes_pls_golite062009
transcription repressor activity	0.72554769377984	bayes_pls_golite062009
sequence-specific DNA binding	0.0852726470007639	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0792897588268993	bayes_pls_golite062009
transcription corepressor activity	0.0736756545988504	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: