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Protein Overview: TFA2

General Information:
Name(s) found: TFA2 / YKR062W [SGD]
Description(s) found:
Found 20 descriptions.
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  • TFIIE small subunit, involved in RNA polymerase II transcription initiation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 328 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIE complex [TASLink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase II promoter [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNRDPLLA NLNAFKSKVK SAPVIAPAKV GQKKTNDTVI TIDGNTRKRT ASERAQENTL  60
   61 NSAKNPVLVD IKKEAGSNSS NAISLDDDDD DEDFGSSPSK KVRPGSIAAA ALQANQTDIS 120
  121 KSHDSSKLLW ATEYIQKKGK PVLVNELLDY LSMKKDDKVI ELLKKLDRIE FDPKKGTFKY 180
  181 LSTYDVHSPS ELLKLLRSQV TFKGISCKDL KDGWPQCDET INQLEEDSKI LVLRTKKDKT 240
  241 PRYVWYNSGG NLKCIDEEFV KMWENVQLPQ FAELPRKLQD LGLKPASVDP ATIKRQTKRV 300
  301 EVKKKRQRKG KITNTHMTGI LKDYSHRV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TFA1 TFA2
    View Details (MIPS) Mewes HW, et al. (2004) TFA1 TFA2
    View Details Krogan NJ, et al. (2006) CWP2 DBP2 FLC2 PPN1 RPS31 SRP40 TFA1 TFA2 YAP1801
    View Details Qiu et al. (2008) SSL1 SSL2 TAF14 TAF2 TFA1 TFA2 TFB1 TFB3 TFB4 TFB5 TFG2 TOA2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TFA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] deduced N/A No confident structure predictions are available.
    2 View Details [97..187] PSI-BLAST 15.69897 The central core domain of TFIIE beta
    3 View Details [188..328] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.67074370996647 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  4.84466441605416 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.57954522145536 bayes_pls_golite062009
  • transcription factor activity
    		•  4.12685284895733 bayes_pls_golite062009
  • binding
    		•  4.05190810999633 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.3918869755162 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.82365519759474 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.82365519759474 bayes_pls_golite062009
  • protein binding
    		•  0.961087148890615 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.237727660028553 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.157471576785569 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.0360186926687502 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle