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Protein Overview: PPN1

General Information:
Name(s) found: PPN1 / YDR452W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 674 amino acids

    Gene Ontology:
    Cellular Component: vacuolar membrane [IDALink to PubMed article][IMPLink to PubMed article]
    Biological Process: polyphosphate metabolic process [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: endopolyphosphatase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVVGKSEVR NVSMSRPKKK SLIAILSTCV LFFLVFIIGA KFQYVSVFSK FLDDRGDNES  60
   61 LQLLNDIEFT RLGLTPREPV IIKDVKTGKE RKLHGRFLHI TDIHPDPYYV EGSSIDAVCH 120
  121 TGKPSKKKDV APKFGKAMSG CDSPVILMEE TLRWIKENLR DKIDFVIWTG DNIRHDNDRK 180
  181 HPRTEAQIFD MNNIVADKMT ELFSAGNEED PRDFDVSVIP SLGNNDVFPH NMFALGPTLQ 240
  241 TREYYRIWKN FVPQQQQRTF DRSASFLTEV IPGKLAVLSI NTLYLFKANP LVDNCNSKKE 300
  301 PGYQLLLWFG YVLEELRSRG MKVWLSGHVP PIAKNFDQSC YDKFTLWTHE YRDIIIGGLY 360
  361 GHMNIDHFIP TDGKKARKSL LKAMEQSTRV QQGEDSNEED EETELNRILD HAMAAKEVFL 420
  421 MGAKPSNKEA YMNTVRDTYY RKVWNKLERV DEKNVENEKK KKEKKDKKKK KPITRKELIE 480
  481 RYSIVNIGGS VIPTFNPSFR IWEYNITDIV NDSNFAVSEY KPWDEFFESL NKIMEDSLLE 540
  541 DEMDSSNIEV GINREKMGEK KNKKKKKNDK TMPIEMPDKY ELGPAYVPQL FTPTRFVQFY 600
  601 ADLEKINQEL HNSFVESKDI FRYEIEYTSD EKPYSMDSLT VGSYLDLAGR LYENKPAWEK 660
  661 YVEWSFASSG YKDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CWP2 DBP2 FLC2 PPN1 RPS31 SRP40 TFA1 TFA2 YAP1801

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PPN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..394] ORFEUS 13.8 Mammalian purple acid phosphatase
    2 View Details [395..674] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  3.9769581188915 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  2.45235251622374 bayes_pls_golite062009
  • phosphatase activity
    		•  2.39240074650203 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.3783355582839 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  2.25095258748144 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.88623145370105 bayes_pls_golite062009
  • catalytic activity
    		•  1.30037658165549 bayes_pls_golite062009
  • binding
    		•  0.908738313033381 bayes_pls_golite062009
  • protein kinase activity
    		•  0.383381160679599 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.260040853463767 bayes_pls_golite062009
  • protein binding
    		•  0.24948140314772 bayes_pls_golite062009
  • kinase activity
    		•  0.210034689968681 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.206833877506643 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle