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Protein Overview: YAP1801

General Information:
Name(s) found: YAP1801 / YHR161C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 637 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed article]
    Biological Process: endocytosis [IPILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: clathrin binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTYFKLVKG ATKIKSAPPK QKYLDPILLG TSNEEDFYEI VKGLDSRIND TAWTIVYKSL  60
   61 LVVHLMIREG SKDVALRYYS RNLEFFDIEN IRGSNGSASG DMRALDRYDN YLKVRCREFG 120
  121 KIKKDYVRDG YRTLKLNSGN YGSSRNKQHS INIALDHVES LEVQIQALIK NKYTQYDLSN 180
  181 ELIIFGFKLL IQDLLALYNA LNEGIITLLE SFFELSHHNA ERTLDLYKTF VDLTEHVVRY 240
  241 LKSGKTAGLK IPVIKHITTK LVRSLEEHLI EDDKTHNTFV PVDSSQGSAG AVVAKSTAQE 300
  301 RLEQIREQKR ILEAQLKNEQ VAISPALTTV TAAQSYNPFG TDSSMHTNIP MAVANQTQQI 360
  361 ANNPFVSQTQ PQVMNTPTAH TEPANLNVPE YAAVQHTVNF NPVQDAGVSA QQTGYYSINN 420
  421 HLTPTFTGAG FGGYSVSQDT TAASNQQVSH SQTGSNNPFA LHNAATIATG NPAHENVLNN 480
  481 PFSRPNFDEQ NTNMPLQQQI ISNPFQNQTY NQQQFQQQKM PLSSINSVMT TPTSMQGSMN 540
  541 IPQRFDKMEF QAHYTQNHLQ QQQQQQQQQQ QQQQQQPQQG YYVPATAGAN PVTNITGTVQ 600
  601 PQNFPFYPQQ QPQPEQSQTQ QPVLGNQYAN NLNLIDM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CWP2 DBP2 FLC2 PPN1 RPS31 SRP40 TFA1 TFA2 YAP1801
    View Details Qiu et al. (2008) ENT1 ENT2 ENT4 RVS167 YAP1801 YAP1802

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YAP1801 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122]
    [167..192]    		 PSI-BLAST 298.519517 Clathrin assembly lymphoid myeloid leukaemia protein, Calm
    2 View Details [123..166]
    [193..271]    		 PSI-BLAST 298.519517 Clathrin assembly lymphoid myeloid leukaemia protein, Calm
    3 View Details [272..338] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [339..637] MSA 43.388997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  2.70535896247543 bayes_pls_golite062009
  • binding
    		•  2.34501465852339 bayes_pls_golite062009
  • protein binding
    		•  1.7891964555817 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.20269437433936 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.87586037360588 bayes_pls_golite062009
  • phospholipid binding
    		•  0.84481265656013 bayes_pls_golite062009
  • lipid binding
    		•  0.176990783274449 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle