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View Structure Prediction Details

Protein: PPN1
Organism: Saccharomyces cerevisiae
Length: 674 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPN1.

Description E-value Query
Range
Subject
Range
PPN1 - Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
PPN1_YEAST - Endopolyphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPN1 PE=1 SV=1
0.0 [1..674] [1..674]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [72..670] [48..663]
PPN1_NEUCR - Endopolyphosphatase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / F...
PPN1_NEUCR - Endopolyphosphatase OS=Neurospora crassa GN=ppn-1 PE=3 SV=2
0.0 [72..670] [22..640]
SPBC713.07c - vacuolar polyphosphatase
PPN1_SCHPO - Endopolyphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ppn1 PE=3 SV=1
0.0 [74..651] [26..524]
SMPD1 - sphingomyelin phosphodiesterase 1, acid lysosomal
0.0 [72..444] [176..543]
ASM_MOUSE - Sphingomyelin phosphodiesterase OS=Mus musculus GN=Smpd1 PE=1 SV=2
0.0 [72..444] [174..541]

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Predicted Domain #1
Region A:
Residues: [1-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVVGKSEVR NVSMSRPKKK SLIAILSTCV LFFLVFIIGA KFQYVSVFSK FLDDRGDNES  60
   61 LQLLNDIEFT RLGLTPREPV IIKDVKTGKE RKLHGRFLHI TDIHPDPYYV EGSSIDAVCH 120
  121 TGKPSKKKDV APKFGKAMSG CDSPVILMEE TLRWIKENLR DKIDFVIWTG DNIRHDNDRK 180
  181 HPRTEAQIFD MNNIVADKMT ELFSAGNEED PRDFDVSVIP SLGNNDVFPH NMFALGPTLQ 240
  241 TREYYRIWKN FVPQQQQRTF DRSASFLTEV IPGKLAVLSI NTLYLFKANP LVDNCNSKKE 300
  301 PGYQLLLWFG YVLEELRSRG MKVWLSGHVP PIAKNFDQSC YDKFTLWTHE YRDIIIGGLY 360
  361 GHMNIDHFIP TDGKKARKSL LKAMEQSTRV QQGE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.8
Match: 1qhwA
Description: Mammalian purple acid phosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 3.9769581188915 bayes_pls_golite062009
phosphoprotein phosphatase activity 2.45235251622374 bayes_pls_golite062009
phosphatase activity 2.39240074650203 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.3783355582839 bayes_pls_golite062009
protein serine/threonine phosphatase activity 2.25095258748144 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.88623145370105 bayes_pls_golite062009
catalytic activity 1.30037658165549 bayes_pls_golite062009
binding 0.908738313033381 bayes_pls_golite062009
protein kinase activity 0.383381160679599 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.260040853463767 bayes_pls_golite062009
protein binding 0.24948140314772 bayes_pls_golite062009
kinase activity 0.210034689968681 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.206833877506643 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [395-674]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSNEEDEETE LNRILDHAMA AKEVFLMGAK PSNKEAYMNT VRDTYYRKVW NKLERVDEKN  60
   61 VENEKKKKEK KDKKKKKPIT RKELIERYSI VNIGGSVIPT FNPSFRIWEY NITDIVNDSN 120
  121 FAVSEYKPWD EFFESLNKIM EDSLLEDEMD SSNIEVGINR EKMGEKKNKK KKKNDKTMPI 180
  181 EMPDKYELGP AYVPQLFTPT RFVQFYADLE KINQELHNSF VESKDIFRYE IEYTSDEKPY 240
  241 SMDSLTVGSY LDLAGRLYEN KPAWEKYVEW SFASSGYKDD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle