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Protein Overview: THO2

General Information:
Name(s) found: THO2 / YNL139C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1597 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    THO complex [IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: mRNA export from nucleus [IMPLink to PubMed article]
    DNA recombination [IMPLink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: nucleic acid binding [IDALink to PubMed article]
    DNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEQTLLSKL NALSQKVIPP ASPSQASILT EEVIRNWPER SKTLCSDFTA LESNDEKEDW  60
   61 LRTLFIELFD FINKNDENSP LKLSDVASFT NELVNHERQV SQASIVGKMF IAVSSTVPNI 120
  121 NDLTTISLCK LIPSLHEELF KFSWISSKLL NKEQTTLLRH LLKKSKYELK KYNLLVENSV 180
  181 GYGQLVALLI LAYYDPDNFS KVSAYLKEIY HIMGKYSLDS IRTLDVILNV SSQFITEGYK 240
  241 FFIALLRKSD SWPSSHVANN SNYSSLNEGG NMIAANIISF NLSQYNEEVD KENYERYMDM 300
  301 CCILLKNGFV NFYSIWDNVK PEMEFLQEYI QNLETELEEE STKGVENPLA MAAALSTENE 360
  361 TDEDNALVVN DDVNMKDKIS EETNADIESK GKQKTQQDIL LFGKIKLLER LLIHGCVIPV 420
  421 IHVLKQYPKV LYVSESLSRY LGRVFEYLLN PLYTSMTSSG ESKDMATALM ITRIDNGILA 480
  481 HKPRLIHKYK THEPFESLEL NSSYVFYYSE WNSNLTPFAS VNDLFENSHI YLSIIGPYLG 540
  541 RIPTLLSKIS RIGVADIQKN HGSESLHVTI DKWIDYVRKF IFPATSLLQN NPIATSEVYE 600
  601 LMKFFPFEKR YFIYNEMMTK LSQDILPLKV SFNKAEREAK SILKALSIDT IAKESRRFAK 660
  661 LISTNPLASL VPAVKQIENY DKVSELVVYT TKYFNDFAYD VLQFVLLLRL TYNRPAVQFD 720
  721 GVNQAMWVQR LSIFIAGLAK NCPNMDISNI ITYILKTLHN GNIIAVSILK ELIITVGGIR 780
  781 DLNEVNMKQL LMLNSGSPLK QYARHLIYDF RDDNSVISSR LTSFFTDQSA ISEIILLLYT 840
  841 LNLKANTQNS HYKILSTRCD EMNTLLWSFI ELIKHCLKGK AFEENVLPFV ELNNRFHLST 900
  901 PWTFHIWRDY LDNQLNSNEN FSIDELIEGA EFSDVDLTKI SKDLFTTFWR LSLYDIHFDK 960
  961 SLYDERKNAL SGENTGHMSN RKKHLIQNQI KDILVTGISH QRAFKKTSEF ISEKSNVWNK1020
 1021 DCGEDQIKIF LQNCVVPRVL FSPSDALFSS FFIFMAFRTE NLMSILNTCI TSNILKTLLF1080
 1081 CCTSSEAGNL GLFFTDVLKK LEKMRLNGDF NDQASRKLYE WHSVITEQVI DLLSEKNYMS1140
 1141 IRNGIEFMKH VTSVFPVVKA HIQLVYTTLE ENLINEERED IKLPSSALIG HLKARLKDAL1200
 1201 ELDEFCTLTE EEAEQKRIRE MELEEIKNYE TACQNEQKQV ALRKQLELNK SQRLQNDPPK1260
 1261 SVASGSAGLN SKDRYTYSRN EPVIPTKPSS SQWSYSKVTR HVDDINHYLA TNHLQKAISL1320
 1321 VENDDETRNL RKLSKQNMPI FDFRNSTLEI FERYFRTLIQ NPQNPDFAEK IDSLKRYIKN1380
 1381 ISREPYPDTT SSYSEAAAPE YTKRSSRYSG NAGGKDGYGS SNYRGPSNDR SAPKNIKPIS1440
 1441 SYAHKRSELP TRPSKSKTYN DRSRALRPTG PDRGDGFDQR DNRLREEYKK NSSQRSQLRF1500
 1501 PEKPFQEGKD SSKANPYQAS SYKRDSPSEN EEKPNKRFKK DETIRNKFQT QDYRNTRDSG1560
 1561 AAHRANENQR YNGNRKSNTQ ALPQGPKGGN YVSRYQR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GBP2 HPR1 HRB1 MFT1 SUB2 TEX1 THO2 THP2
    View Details Krogan NJ, et al. (2006) CPR7 GBP2 GVP36 HHO1 HPR1 HRB1 MFT1 SUB2 TEX1 THO2 THP2 ULS1 YNL140C
    View Details Gavin AC, et al. (2006) HPR1 HRB1 MFT1 SUB2 TEX1 THO2 THP2
    View Details Gavin AC, et al. (2002) AIR2 BRR1 BUR2 CBC2 HTA1 KAP95 LUC7 MSH4 MUD1 NAB3 NAB6 NAM8 NPL3 NRD1 NUP60 PRP39 PRP40 PRP42 RSE1 SCP160 SEN1 SGV1 SMD1 SMD2 SMD3 SNP1 SNU56 SNU71 SRO9 SRP1 STO1 THO2 TIF4631 TIF4632 YRA2
    View Details Ho Y, et al. (2002) AHA1 BCY1 CAR2 CYS4 DIS3 EAF3 FIP1 GBP2 GND1 GTO1 HAS1 HPR1 IMD3 KAP95 LAA1 LYS1 MES1 MFT1 NAM8 NOP6 NUP1 NUP2 NUP60 PAP1 PCT1 PRB1 REB1 RNT1 RRP4 RRP43 RRP6 RTT103 SAH1 SIF2 SIN3 SNO2 SNU56 SRP1 SSK2 SSN8 STO1 SUB2 TEX1 THI22 THO2 THP2 TIF1, TIF2 TPK2 TPK3 TRA1 UME1 VPS21 YBR028C YCK1 YCK2 YCK3 YGR111W YPR090W YPT53 YRA1
    View Details Qiu et al. (2008) HPR1 MFT1 SUB2 THO2 THP2 YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data THO2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1111] deduced N/A No confident structure predictions are available.
    2 View Details [1112..1489] PSI-BLAST 22.39794 Heavy meromyosin subfragment
    3 View Details [1490..1597] MSA 2.662996 View MSA. No confident structure predictions are available.
    4 View Details [515..743] deduced N/A No confident structure predictions are available.
    5 View Details [744..958] deduced N/A No confident structure predictions are available.
    6 View Details [959..1087] deduced N/A No confident structure predictions are available.
    7 View Details [1088..1514] PSI-BLAST 23.0 Heavy meromyosin subfragment
    8 View Details [1515..1597] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle