Protein Overview: SWC3

General Information:
Name(s) found:	SWC3 / YAL011W [SGD]
Description(s) found: Found 20 descriptions. SHOW ALL	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae [SGD]
Organism:	Saccharomyces cerevisiae
Length:	625 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] mitochondrion [IDA ] Swr1 complex [IDA ]
Biological Process:	chromatin remodeling [IDA][IGI][IMP] response to drug [IMP] histone exchange [IPI] endoplasmic reticulum organization [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAVLRTRSK ESSIEQKPAS RTRTRSRRGK RGRDDDDDDD DEESDDAYDE VGNDYDEYAS  60
   61 RAKLATNRPF EIVAGLPASV ELPNYNSSLT HPQSIKNSGV LYDSLVSSRR TWVQGEMFEL 120
  121 YWRRPKKIVS ESTPAATESP TSGTIPLIRD KMQKMCDCVM SGGPHTFKVR LFILKNDKIE 180
  181 QKWQDEQELK KKEKELKRKN DAEAKRLRME ERKRQQMQKK IAKEQKLQLQ KENKAKQKLE 240
  241 QEALKLKRKE EMKKLKEQNK NKQGSPSSSM HDPRMIMNLN LMAQEDPKLN TLMETVAKGL 300
  301 ANNSQLEEFK KFIEIAKKRS LEENPVNKRP SVTTTRPAPP SKAKDVAEDH RLNSITLVKS 360
  361 SKTAATEPEP KKADDENAEK QQSKEAKTTA ESTQVDVKKE EEDVKEKGVK SEDTQKKEDN 420
  421 QVVPKRKRRK NAIKEDKDMQ LTAFQQKYVQ GAEIILEYLE FTHSRYYLPK KSVVEFLEDT 480
  481 DEIIISWIVI HNSKEIEKFK TKKIKAKLKA DQKLNKEDAK PGSDVEKEVS FNPLFEADCP 540
  541 TPLYTPMTMK LSGIHKRFNQ IIRNSVSPME EVVKEMEKIL QIGTRLSGYN LWYQLDGYDD 600
  601 EALSESLRFE LNEWEHAMRS RRHKR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ARP4 ARP6 BDF1 RVB1 RVB2 SWC3 SWC4 SWC5 SWR1 VPS71 VPS72 YAF9
View Details	Krogan NJ, et al. (2006)		ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	SWC3	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SWC3	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..142]	deduced	N/A	No confident structure predictions are available.
2	View Details	[143..314]	deduced	N/A	No confident structure predictions are available.
3	View Details	[315..625]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2