Protein Overview: UBC7

General Information:
Name(s) found:	UBC7 / YMR022W [SGD]
Description(s) found: Found 38 descriptions. SHOW ALL	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly [SGD]
Organism:	Saccharomyces cerevisiae
Length:	165 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum [TAS]
Biological Process:	chromatin assembly or disassembly [IMP] ER-associated protein catabolic process [IDA][IGI][IMP]
Molecular Function:	ubiquitin-protein ligase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKTAQKRLL KELQQLIKDS PPGIVAGPKS ENNIFIWDCL IQGPPDTPYA DGVFNAKLEF  60
   61 PKDYPLSPPK LTFTPSILHP NIYPNGEVCI SILHSPGDDP NMYELAEERW SPVQSVEKIL 120
  121 LSVMSMLSEP NIESGANIDA CILWRDNRPE FERQVKLSIL KSLGF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		AHP1 BCY1 SSK1 SSK2 UBC7 UBI4

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	MDS3	2	Unpublished Fields Lab Data
View Screen	UBC7	YRR1	2	Unpublished Fields Lab Data
View Screen	UBC7	YSY6	2	Unpublished Fields Lab Data
View Screen	UBC7	YGL230C	2	Unpublished Fields Lab Data
View Screen	UBC7	ALG5	2	Unpublished Fields Lab Data
View Screen	UBC7	YOR392W	2	Unpublished Fields Lab Data
View Screen	UBC7	AST1	2	Unpublished Fields Lab Data
View Screen	UBC7	YLR076C	2	Unpublished Fields Lab Data
View Screen	UBC7	YPL107W	2	Unpublished Fields Lab Data
View Screen	UBC7	ULI1	2	Unpublished Fields Lab Data
View Screen	UBC7	YPR150W	2	Unpublished Fields Lab Data
View Screen	UBC7	CPR4	2	Unpublished Fields Lab Data
View Screen	UBC7	YKL053W	2	Unpublished Fields Lab Data
View Screen	UBC7	TRE2	2	Unpublished Fields Lab Data
View Screen	UBC7	VPS16	2	Unpublished Fields Lab Data
View Screen	UBC7	PEX8	2	Unpublished Fields Lab Data
View Screen	UBC7	NUP100	2	Unpublished Fields Lab Data
View Screen	UBC7	PSR2	2	Unpublished Fields Lab Data
View Screen	UBC7	RPS31	2	Unpublished Fields Lab Data
View Screen	UBC7	RSM19	2	Unpublished Fields Lab Data
View Screen	UBC7	YBR064W	2	Unpublished Fields Lab Data
View Screen	UBC7	IOC4	2	Unpublished Fields Lab Data
View Screen	UBC7	SWC3	2	Unpublished Fields Lab Data
View Screen	UBC7	YLR352W	2	Unpublished Fields Lab Data
View Screen	UBC7	TMA29	2	Unpublished Fields Lab Data
View Screen	UBC7	TRM112	2	Unpublished Fields Lab Data
View Screen	UBC7	YPR196W	2	Unpublished Fields Lab Data
View Screen	UBC7	ATP4	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	UBC7	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..165]	PSI-BLAST	916.37734	Ubiquitin conjugating enzyme, UBC

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
ubiquitin-protein ligase activity	11.3486134076304	bayes_pls_golite062009
small conjugating protein ligase activity	11.2964721480824	bayes_pls_golite062009
acid-amino acid ligase activity	10.2401422444624	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	8.93602533934698	bayes_pls_golite062009
HLH domain binding	8.10904818707269	bayes_pls_golite062009
ligase activity	5.89730943108033	bayes_pls_golite062009
SUMO ligase activity	3.88357560284404	bayes_pls_golite062009
ISG15 ligase activity	3.37361650623694	bayes_pls_golite062009
NEDD8 ligase activity	3.30521803258995	bayes_pls_golite062009
transcription regulator activity	2.21355731489173	bayes_pls_golite062009
nucleic acid binding	2.13970605403492	bayes_pls_golite062009
DNA binding	1.95596447916631	bayes_pls_golite062009
protein binding	1.77678273247394	bayes_pls_golite062009
binding	1.75350658654805	bayes_pls_golite062009
transcription repressor activity	1.5236035191291	bayes_pls_golite062009
transcription activator activity	1.19240180311941	bayes_pls_golite062009
catalytic activity	0.891402822028799	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.58835335751383	bayes_pls_golite062009
kinase activity	0.519703305315987	bayes_pls_golite062009
protein kinase activity	0.443948654247666	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.373779304908933	bayes_pls_golite062009
small protein activating enzyme activity	0.36227294335656	bayes_pls_golite062009
protein serine/threonine kinase activity	0.182854082413338	bayes_pls_golite062009
transcription corepressor activity	0.122859425935324	bayes_pls_golite062009
transferase activity	0.0984525836903841	bayes_pls_golite062009
transcription factor binding	0.0104967529560147	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2