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The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ER-associated protein catabolic process
Acc: GO:0030433
Aspect: Biological Process
Desc: The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.
Synonyms:
  • ERAD
  • ER-associated protein breakdown
  • ER-associated protein catabolism
  • endoplasmic reticulum-associated protein catabolism
  • endoplasmic reticulum-associated protein catabolic process
  • ER-associated protein degradation
Proteins in PDR annotated with:
   This term: 131 [Search]
   Term or descendants: 131 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030433 - ER-associated protein catabolic process (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle