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Protein Overview: TRE2

General Information:
Name(s) found: TRE2 / YOR256C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 809 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: ubiquitin-dependent protein catabolic process [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSSYQPVST TNFEHENAIP TASSSHNLLM SQRFDDSPPS SNDNSIETNI TPPPEPPSYE  60
   61 FDIEDPHDDL HKRTHLQRVS IGFQEKILEP LMENIIHPLL QISKFVPDKA DYYLSKIGNP 120
  121 FILRRFFYII FMSFIAYYVL SSGYLFNEKA SGSKGMFSQH DILFEYAKKS VDLAKFERDL 180
  181 EYISSMPHGS GTKGDAAIYR YIQESFDNNG LKLVKEMGYS VYSNYPGNVS ISYYDNKNEK 240
  241 HDLELSKENF NPLSSNGKLS KVSLIYGGKG TTYDLQHLKD SKTIEDGKDY VLLLQYDKLV 300
  301 SQQVLIAEKF GAKAVIFISE PYGENIDVVQ SKPVGLPQYS TGDASGLNWD GSPVEEKDHK 360
  361 FWRQTHIPTI PISTRQGKEL LSRLSSGGVT VDDGNSDRSN SGKMGDVLID VDLQTNVREK 420
  421 HFIPNIVGKI EGREQSDKAI IIAASRNSIN FGTTYPNFGT AALLSIVQLF QEVKYKFGWK 480
  481 PLRNIYFISF GGTEFNYAGS SELVEQRLTP LKDEIYSLID ISQLGIPFAE KYENGKTRGE 540
  541 LSIETHPLLK KFFNRNAHGN FDISVDNVQH YGDWTPFLAN GIPVSVISSD STRNRDTPTE 600
  601 TSEDKFERVE KILEDEQNQQ SVKDLLVYLL HISMELIDDP LLHFDIISYV EDIDERLQRL 660
  661 EQAYPEKLNF TSIIKGLLFW KKIGSEWASW TQGWENIVWS HGDGIEPSLL SINRWTWNKK 720
  721 LTNIGRRTCS PAGLPNRSFY KNVLFGPTLI QEDKSKNGGN VDFWTFPGVM DAIYDDDWKR 780
  781 AQEQIDLIGK VLHQSAALFV EETNDIGYK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 TRE2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] deduced N/A No confident structure predictions are available.
    2 View Details [152..224]
    [338..363]
    [418..636]    		 PSI-BLAST 243.0103 Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
    3 View Details [225..337]
    [364..417]
    [637..809]    		 PSI-BLAST 243.0103 Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.64510404037841 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.26499474130077 bayes_pls_golite062009
  • hydrolase activity
    		•  2.98013991489506 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.66431152897721 bayes_pls_golite062009
  • receptor activity
    		•  2.50668975998057 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.43554678928141 bayes_pls_golite062009
  • signal transducer activity
    		•  2.43554678928141 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.04062448553328 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.5759162922092 bayes_pls_golite062009
  • catalytic activity
    		•  1.3989281287879 bayes_pls_golite062009
  • binding
    		•  1.13031326446259 bayes_pls_golite062009
  • transferrin receptor activity
    		•  1.08060244646522 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  0.891655769761122 bayes_pls_golite062009
  • metalloexopeptidase activity
    		•  0.472688733072762 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.454707207494165 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.204452912688153 bayes_pls_golite062009
  • metallocarboxypeptidase activity
    		•  0.180859448845431 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.175639750716837 bayes_pls_golite062009
  • DNA binding
    		•  0.115087846898245 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.0966237570696103 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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