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View Structure Prediction Details

Protein: TRE2
Organism: Saccharomyces cerevisiae
Length: 809 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRE2.

Description E-value Query
Range		 Subject
Range
TRE2 - Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal t...
TRE2_YEAST - Putative zinc metalloprotease TRE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRE2 ...
 0.0 [1..809] [1..809]
FOLH1 - folate hydrolase (prostate-specific membrane antigen) 1
 0.0 [124..803] [17..750]
FOLH1_RAT - Glutamate carboxypeptidase 2 OS=Rattus norvegicus GN=Folh1 PE=1 SV=1
 0.0 [124..802] [17..751]
FOLH1_PIG - Glutamate carboxypeptidase 2 OS=Sus scrofa GN=FOLH1 PE=1 SV=1
 0.0 [124..803] [17..751]
gi|31980800, gi|... - gi|31980800|ref|NP_058050.2| folate hydrolase [Mus musculus], gi|12833259|dbj|BAB22457.1| unnamed pr...
 0.0 [124..803] [17..752]
TFR1_CANLF - Transferrin receptor protein 1 OS=Canis lupus familiaris GN=TFRC PE=1 SV=1
 0.0 [159..778] [135..764]

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Predicted Domain #1
Region A:
Residues: [1-151] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSSYQPVST TNFEHENAIP TASSSHNLLM SQRFDDSPPS SNDNSIETNI TPPPEPPSYE  60
   61 FDIEDPHDDL HKRTHLQRVS IGFQEKILEP LMENIIHPLL QISKFVPDKA DYYLSKIGNP 120
  121 FILRRFFYII FMSFIAYYVL SSGYLFNEKA S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [152-224] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSKGMFSQHD ILFEYAKKSV DLAKFERDLE YISSMPHGSG TKGDAAIYRY IQESFDNNGL  60
   61 KLVKEMGYSV YSN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [338-363] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYSTGDASGL NWDGSPVEEK DHKFWR

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [418-636] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REKHFIPNIV GKIEGREQSD KAIIIAASRN SINFGTTYPN FGTAALLSIV QLFQEVKYKF  60
   61 GWKPLRNIYF ISFGGTEFNY AGSSELVEQR LTPLKDEIYS LIDISQLGIP FAEKYENGKT 120
  121 RGELSIETHP LLKKFFNRNA HGNFDISVDN VQHYGDWTPF LANGIPVSVI SSDSTRNRDT 180
  181 PTETSEDKFE RVEKILEDEQ NQQSVKDLLV YLLHISMEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 243.0103
Match: 1de4C_
Description: Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.64510404037841 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.26499474130077 bayes_pls_golite062009
hydrolase activity 2.98013991489506 bayes_pls_golite062009
transmembrane receptor activity 2.66431152897721 bayes_pls_golite062009
receptor activity 2.50668975998057 bayes_pls_golite062009
molecular transducer activity 2.43554678928141 bayes_pls_golite062009
signal transducer activity 2.43554678928141 bayes_pls_golite062009
metallopeptidase activity 2.04062448553328 bayes_pls_golite062009
exopeptidase activity 1.5759162922092 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
binding 1.13031326446259 bayes_pls_golite062009
transferrin receptor activity 1.08060244646522 bayes_pls_golite062009
carboxypeptidase activity 0.891655769761122 bayes_pls_golite062009
metalloexopeptidase activity 0.472688733072762 bayes_pls_golite062009
nucleic acid binding 0.454707207494165 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.204452912688153 bayes_pls_golite062009
metallocarboxypeptidase activity 0.180859448845431 bayes_pls_golite062009
transcription regulator activity 0.175639750716837 bayes_pls_golite062009
DNA binding 0.115087846898245 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [225-337] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPGNVSISYY DNKNEKHDLE LSKENFNPLS SNGKLSKVSL IYGGKGTTYD LQHLKDSKTI  60
   61 EDGKDYVLLL QYDKLVSQQV LIAEKFGAKA VIFISEPYGE NIDVVQSKPV GLP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [364-417] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTHIPTIPIS TRQGKELLSR LSSGGVTVDD GNSDRSNSGK MGDVLIDVDL QTNV

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [637-809] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDDPLLHFDI ISYVEDIDER LQRLEQAYPE KLNFTSIIKG LLFWKKIGSE WASWTQGWEN  60
   61 IVWSHGDGIE PSLLSINRWT WNKKLTNIGR RTCSPAGLPN RSFYKNVLFG PTLIQEDKSK 120
  121 NGGNVDFWTF PGVMDAIYDD DWKRAQEQID LIGKVLHQSA ALFVEETNDI GYK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 243.0103
Match: 1de4C_
Description: Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle