YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: IOC4

General Information:
Name(s) found: IOC4 / YMR044W [SGD]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 475 amino acids

    Gene Ontology:
    Cellular Component: ISW1 complex [IPILink to PubMed article]
    Biological Process: chromatin remodeling [IPILink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEAIFQPTD IVLAKVKGFS AWPAMIIPNE LIPDNILKTK PVSVHKGKSG SDKKANEDID  60
   61 ADMESEARDR EQSEEEEDIE DFGESEANPE KFIIYTPVLK FRKNDTLKST YCVKFFCDDS 120
  121 YIWVKPMDMK ILTSEDCRKW LSGKQRKNKK LIPAYEMAMR GKNGIDIWEF VEYGSYGKPD 180
  181 EEEYVEEEEE ENEPEKKAIR PTRSSSRQRQ KRASETEKSE GGNSNKRKRV TRSTRQQAID 240
  241 ASEEEEEEEE EKVQEAVRKR PQRTKTKKVV VSKTKPNPKT KAKKEKPKPP KPIKYHFEDD 300
  301 EDWSIVGLGP QDLSIEKTMD PIAKKLSQKK NLEKHVEIKL DLEDKLAGIN KLLCDVLCSA 360
  361 INQAVSIKDD FEIILDELQI ALDTRGSRNE FITIFQSNNS LLLNFRILFN LRKRELNKWD 420
  421 LWDRFQDIFK HIYSYQFIPD TEDWQLEQNM EIEEMDREKP SFSEDVKEEE SKVGA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) IOC2 IOC4
    View Details Krogan NJ, et al. (2006) ESC8 IOC2 IOC3 IOC4 ISW1 YJL068C
    View Details Qiu et al. (2008) IOC2 IOC3 IOC4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 IOC4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IOC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] Pfam 23.638272 PWWP domain No confident structure predictions are available.
    2 View Details [104..418] MSA 17.242997 View MSA. No confident structure predictions are available.
    3 View Details [419..475] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.45928671861254 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.24722861476275 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.55219533482531 bayes_pls_golite062009
  • histone binding
    		•  2.26545558774373 bayes_pls_golite062009
  • DNA binding
    		•  2.10892266989425 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  2.01216822303077 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  2.01216822303077 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  2.01216822303077 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.96501079412108 bayes_pls_golite062009
  • protein binding
    		•  1.84773537446909 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.7489342678155 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.38876191465165 bayes_pls_golite062009
  • transcription factor binding
    		•  1.32624006699374 bayes_pls_golite062009
  • transcription factor activity
    		•  1.19430233104619 bayes_pls_golite062009
  • methylated histone residue binding
    		•  1.1690628420074 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.15814615779914 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.883512085043854 bayes_pls_golite062009
  • chromatin binding
    		•  0.563534016927931 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.422700451906002 bayes_pls_golite062009
  • transcription activator activity
    		•  0.23424395939437 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0867039973523847 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0205412614883955 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle