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Protein Overview: ESC8

General Information:
Name(s) found: ESC8 / YOL017W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 714 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: chromatin silencing [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEIIDLDLV DDFIKKPMVK QQKNQSSKPR VKRRGQLTFD DFRNIKIVEE PVVLSHNSSI  60
   61 DESLDAATQN TKKREKYEGT CDEEMKTKEM EANMASKYSN IKTHSNDTNK VESISEHTTS 120
  121 NNRPLNTLNW SPNIPLRYSD FAKFMSDETV TESNWAPPLC TPLPYAGDVM KILSFIVKFK 180
  181 WVFSDDLLNL SFQDVEIGLE LKVAGHSAKN IRICQDKMNL LFCSLLRLLF CSEKRADNQT 240
  241 HRNFTLKRFL SLKNPYGKLV GKLRSLIQEW GLPKEWRGNS DILSTLNFNG GGLLTMEPLD 300
  301 RIILLRCMID WNCSYSALFH NEIQRLTHLK GDTGFNHQTF HASRFAMCGA NNILDSCEVL 360
  361 CSLMSQKLEN RKKRKPSDKG KLSKINSQMK FLKGVRKSLS EKVTTDRLRA AVKINEEWGE 420
  421 YFANEFTHTP IDDPTVDEIY KLRTSEFMIA RIPRVGDFYL PPFWIGNECS SVNTSYSFND 480
  481 MSTYLNYFVK FKEEGTKILP AKTAQNENKC QLKLIYRNTP ACIRNLQFND VHFAEVPHWF 540
  541 EVAGDSNSLS NFIEYLESLS SLTENDTDDT KKGIDNLIEF LKIFSIFINE TIQRITAAPT 600
  601 GSTEGRHLRT SSQRRTTVHY SSDVNGDVSE ESENEVDIDV SDDYDSEYLS EENTLTRKGE 660
  661 DRTDKSFGKR ELHNGAKDCD RNCDDIEIFS EPVRQLQDNS REKRSLRRNA RKGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ESC8 IOC2 IOC3 IOC4 ISW1 YJL068C
    View Details Gavin AC, et al. (2002) ACT1 ADH1 ARP4 ARP8 ESC8 GCN1 IES1 IES5 INO80 IOC3 ISW1 ISW2 ITC1 MOT1 NHP10 NPL6 PDC1 RPC40 RSC2 RSC4 RSC58 RSC6 RSC8 RVB2 SIN3 SPT15 VPS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ESC8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..599] MSA 1.002 View MSA. No confident structure predictions are available.
    2 View Details [600..714] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle