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Protein Overview: SSK1

General Information:
Name(s) found: SSK1 / YLR006C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 712 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [TASLink to PubMed article]
    Biological Process: osmosensory signaling pathway via two-component system [IDALink to PubMed article][TASLink to PubMed article]
    response to hydrogen peroxide [IMPLink to PubMed article]
    Molecular Function: enzyme activator activity [TASLink to PubMed article]
    two-component response regulator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNSALLWKV WLRIDNSTDE VNQPIAVQFD EIDTVDDLKS RFFQKLSSTR WREINDNASI  60
   61 AIGLYAPKFD NQADNTSSNN TNDNSCRSKS NGAGSGANLS VNSNTKSSVS PTAGSFGLSK 120
  121 DLAKDRNVLQ HPKPTQKRGA LYDAFAAVPT VAATTNVDFP PNEAPMLSPQ RPYSTSPKQF 180
  181 PATTKSPLLR FASVSPYPKF HSDNQIMASA GLTYVSPHNK NKYTRPLIRK GLNFTTESVN 240
  241 DCTYKIIFEP DELAINIYKE LFGTMGSQPA SQPLLIFSNV NLRQDVPPLD ILNVVDYVPT 300
  301 NEEISQQKTQ PTDHGAVGVF HLDDHISPGE QGLKQTIGDK ADLKGKDGNS SPQEFKLITD 360
  361 EEQLRRASQE LKDEEKDAES PWQAILLLPK GYKGGVDFRN KPVAHTDSSF NNEDTITHSE 420
  421 LEVNTGSPSQ ESGSLNEAGI GITQPMSEVQ RRKEDVTPAS PILTSSQTPH YSNSLYNAPF 480
  481 AVSSPPDPLP NLFTTTSEKV FPKINVLIVE DNVINQAILG SFLRKHKISY KLAKNGQEAV 540
  541 NIWKEGGLHL IFMDLQLPVL SGIEAAKQIR DFEKQNGIGI QKSLNNSHSN LEKGTSKRFS 600
  601 QAPVIIVALT ASNSQMDKRK ALLSGCNDYL TKPVNLHWLS KKITEWGCMQ ALIDFDSWKQ 660
  661 GESRMTDSVL VKSPQKPIAP SNPHSFKQAT SMTPTHSPVR KNSNLSPTQI EL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SSK1 SSK2
    View Details Krogan NJ, et al. (2006) SSK1 SSK2
    View Details Ho Y, et al. (2002) EST1 SLX5 SSK1 SSK2 SSK22 UBC7

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SSK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] deduced N/A No confident structure predictions are available.
    2 View Details [184..314] MSA 4.153996 View MSA. No confident structure predictions are available.
    3 View Details [315..497] PSI-BLAST 13.69897 Histidine kinase domain of the osmosensor EnvZ
    4 View Details [498..712] PSI-BLAST 41.522879 PhoB; PhoB receiver domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle