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Protein Overview: EST1

General Information:
Name(s) found: EST1 / YLR233C [SGD]
Description(s) found:
Found 23 descriptions.
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  • TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 699 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    telomerase holoenzyme complex [IDALink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    telomere maintenance via telomerase [TASLink to PubMed article]
    Molecular Function: telomerase activity [IDALink to PubMed article][IPILink to PubMed article]
    RNA binding [IPILink to PubMed article]
    single-stranded DNA binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNEEVNEEC MRLFFKNARA HLDKHLTSRL TCDENAYITF RCFLDGIHRK STRFLEELLL  60
   61 KQENMYHNNN YERINDSVIP LVLKLLWLQI HEPTLQWFEH WFHDIMRLSN RRKFRVFRIF 120
  121 QKKMIQFFKI THRYYYDIIE HLCAKYDMNS VISNALFAKL NLMQYTDGLS THEKIILNTS 180
  181 NPLTFSIVIS LQRCVINLGS THFYKTLLNK PSNKPKSVEG FEKSIRYLNI ASLYLPAVGD 240
  241 TYFQRAKIYL ITGKFSLYFF ELVRGALVRI PSKCALNNLK DFILTPDFPE RRRLMKKLAI 300
  301 LVSKDLKGEK SFFEGQIVLQ FLSIVEHTLV PQSWNASRAS NCWLLKEHLQ MAALKYHSGN 360
  361 INVILENLAA TMGSFDLMFT TRKSKEQKNK LKYADLSERQ VFFLDLSFDF IANIIDVVIK 420
  421 PSWQKNMEDF RYLAIIRLLM CWIKSYRSIL QYTHRHRKFC TSFALLLNDL INSPLNCSGN 480
  481 IYSHRPKRSY LFREDIIFRE FSCINFALTD FNDDYVYDSP DMINNIIGCP TLTKVLSPKE 540
  541 ECVLRIRSII FSGMKFLEKN DTGVIWNASK YKFDLISPNI KIKRQIALSE ISSKINVKTQ 600
  601 QERVVSSRKV EAKRDEQQRK RAGKIAVTEL EKQFANVRRT KKLSPLPEKD GVSSELVKHA 660
  661 ASRGRKTITG PLSSDFLSYP DEAIDADEDI TVQVPDTPT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) EST1 EST2 EST3
    View Details Ho Y, et al. (2002) CBF5 DBP7 EST1 HSH49 KRE33 MRM1 MSS116 PDI1 PUF6 PWP1 RPF2 RRP1 RRP12 SSK1 SSK2 SSK22 URB1 UTP10 YER077C
    View Details Qiu et al. (2008) EST1 EST2 EST3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen EST1 MPS3 2 Uetz P, et al. (2000)
    View Screen EST1 FRT2 2 Uetz P, et al. (2000)
    View Screen EST1 MCM6 2 Unpublished Fields Lab Data
    View Screen EST1 SPT23 2 Uetz P, et al. (2000)
    View Screen EST1 URE2 2 Uetz P, et al. (2000)
    View Screen EST1 YGR160W 2 Uetz P, et al. (2000)
    View Screen EST1 YMD8 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..471] ORFEUS 10.41 Clathrin heavy chain proximal leg segment
    2 View Details [472..699] deduced N/A No confident structure predictions are available.
    3 View Details [286..618] FFAS03 2.32 Crystal structure of the N-terminal domain of human SMG7
    4 View Details [619..699] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.45002000313605 bayes_pls_golite062009
  • protein binding
    		•  1.41340296563325 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.03214696367403 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.0247488240855 bayes_pls_golite062009
  • DNA binding
    		•  0.812129701902081 bayes_pls_golite062009
  • transcription factor activity
    		•  0.142011117504773 bayes_pls_golite062009
  • RNA binding
    		•  0.0778145706670981 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle