YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: EST2

General Information:
Name(s) found: EST2 / YLR318W [SGD]
Description(s) found:
Found 18 descriptions.
SHOW ALL
  • Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 884 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    telomerase holoenzyme complex [IDALink to PubMed article][IPILink to PubMed article]
    nucleolus [IDALink to PubMed article]
    telomerase catalytic core complex [IDALink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    telomere maintenance via telomerase [IDALink to PubMed article][IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: telomerase activity [IDALink to PubMed article]
    telomeric template RNA reverse transcriptase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKILFEFIQD KLDIDLQTNS TYKENLKCGH FNGLDEILTT CFALPNSRKI ALPCLPGDLS  60
   61 HKAVIDHCII YLLTGELYNN VLTFGYKIAR NEDVNNSLFC HSANVNVTLL KGAAWKMFHS 120
  121 LVGTYAFVDL LINYTVIQFN GQFFTQIVGN RCNEPHLPPK WVQRSSSSSA TAAQIKQLTE 180
  181 PVTNKQFLHK LNINSSSFFP YSKILPSSSS IKKLTDLREA IFPTNLVKIP QRLKVRINLT 240
  241 LQKLLKRHKR LNYVSILNSI CPPLEGTVLD LSHLSRQSPK ERVLKFIIVI LQKLLPQEMF 300
  301 GSKKNKGKII KNLNLLLSLP LNGYLPFDSL LKKLRLKDFR WLFISDIWFT KHNFENLNQL 360
  361 AICFISWLFR QLIPKIIQTF FYCTEISSTV TIVYFRHDTW NKLITPFIVE YFKTYLVENN 420
  421 VCRNHNSYTL SNFNHSKMRI IPKKSNNEFR IIAIPCRGAD EEEFTIYKEN HKNAIQPTQK 480
  481 ILEYLRNKRP TSFTKIYSPT QIADRIKEFK QRLLKKFNNV LPELYFMKFD VKSCYDSIPR 540
  541 MECMRILKDA LKNENGFFVR SQYFFNTNTG VLKLFNVVNA SRVPKPYELY IDNVRTVHLS 600
  601 NQDVINVVEM EIFKTALWVE DKCYIREDGL FQGSSLSAPI VDLVYDDLLE FYSEFKASPS 660
  661 QDTLILKLAD DFLIISTDQQ QVINIKKLAM GGFQKYNAKA NRDKILAVSS QSDDDTVIQF 720
  721 CAMHIFVKEL EVWKHSSTMN NFHIRSKSSK GIFRSLIALF NTRISYKTID TNLNSTNTVL 780
  781 MQIDHVVKNI SECYKSAFKD LSINVTQNMQ FHSFLQRIIE MTVSGCPITK CDPLIEYEVR 840
  841 FTILNGFLES LSSNTSKFKD NIILLRKEIQ HLQAYIYIYI HIVN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) EST1 EST2 EST3
    View Details Qiu et al. (2008) EST1 EST2 EST3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..301] deduced N/A No confident structure predictions are available.
    2 View Details [302..584] MSA 2.423994 View MSA. No confident structure predictions are available.
    3 View Details [585..773] PSI-BLAST 3.69897 MMLV reverse transcriptase
    4 View Details [774..884] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [583..747] PSI-BLAST 5.0 Arginine 116 is Essential for Nucleic Acid Recognition by the Fingers Domain of Moloney Murine Leukemia Virus Reverse Transcriptase
    6 View Details [748..884] MSA 2.583989 View MSA. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle