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Protein Overview: SPT23

General Information:
Name(s) found: SPT23 / YKL020C [SGD]
Description(s) found:
Found 24 descriptions.
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  • ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1082 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article][TASLink to PubMed article]
    nucleus [ICLink to PubMed article]
    Biological Process: response to cold [IEPLink to PubMed article][IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    fatty acid metabolic process [IMPLink to PubMed article]
    Molecular Function: DNA binding [IPILink to PubMed article]
    transcription activator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSGTGNVSS MLHSYSANIQ HNDGSPDLDL LESELLDIAL LNSGSSLQDP GLLSLNQEKM  60
   61 ITAGTTTPGK EDEGELRDDI ASLQGLLDRH VQFGRKLPLR TPYANPLDFI NINPQSLPLS 120
  121 LEIIGLPKVS RVETQMKLSF RIRNAHARKN FFIHLPSDCI AKDKFFTSSD DPTNLTIPNR 180
  181 DINERTLFLD AFLLCASNNN SNNFKQTYVC NRCINREKRR ASRRKSGLND NSIWQNNENK 240
  241 RAIIFNSKQL FIISNNGLSG NSNCINFDLP TRIVCYCRHH KATNGFVVLF LLRDHNGDIL 300
  301 AKTITDPIMI MDKKNASNTT TPTSTSNAQV SPMTNDTRSF SSPQSDLNFP SEFPLPSNSK 360
  361 NFVISTNCML DSNCNNNNND NDNKNNIKTN TAMMNNNRHF PSPNSSSEDS NHSFSDIHFS 420
  421 NNNDNNLHRS LDSWSSTGFN SSSNPALTTL TSDFSAASAR HTGKRQRSVN EPFMSTPNTF 480
  481 SRLPQKFIDS SKDISNHNSV PVALNNKPSI QRVIPAQGSI NGGIEVTLLG SKFKQGLIIK 540
  541 FGENIALSSQ CWNESTMVTY LPPSSKPGPV LVTIVDPSET SMRNNSNSSV STSNSTNDIL 600
  601 HLNKYTGEKA IFTYVDDTDR QLIELALQIV GLKMNGKLED ARNIAKRIVG SDSSPSNNNA 660
  661 GLHSQNSSLN SYTNMMRNIN DEQLITEVIK SFKRNNNLST VNLSMCDVRG RTLLHLAAFN 720
  721 NWYSLVSLLI KYGSHLNDQD LFGFTPLHMA CINGDLRIIR LLLECNVNIM KKTRNGFIAK 780
  781 QFFLMNYTVN KTRYSNYETS LFDDILTRLT KNTTGSSDTQ PFERNVSQSS FNSSLFDDDD 840
  841 ADHDYVQERK YLLADSAALA PEQSNCNDNT SFSILDSDSG YDISDCESSS DEIALEFFNT 900
  901 HKIKDFSSKP NEIPKTTKTS IEPDGSLWNR MLTRLNDELP KYEDLFPKKP KNWELGSKSV 960
  961 EIGPDNSAQM TVDDSQTSSE DDELEALQVG FNTIFSKKQN FQNDKMLLFF WIPLTLVLLL1020
 1021 CFTLSNLGKD DDMFHNLSKI VQEYLRIGLA KVLLGNERMK TSFKMQLSKF QNNNILNDMR1080
 1081 VN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MGA2 SPT23

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen EST1 SPT23 2 Uetz P, et al. (2000)
    View Screen YIF1 SPT23 2 Unpublished Fields Lab Data
    View Screen NUP1 SPT23 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SPT23 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..181] deduced N/A No confident structure predictions are available.
    2 View Details [182..500] MSA 2.207963 View MSA. No confident structure predictions are available.
    3 View Details [501..585] Pfam 12.236572 IPT/TIG domain No confident structure predictions are available.
    4 View Details [586..660] PSI-BLAST 71.228787 I-kappa-B-alpha
    5 View Details [661..737] PSI-BLAST 71.228787 I-kappa-B-alpha
    6 View Details [738..799] PSI-BLAST 71.228787 I-kappa-B-alpha
    7 View Details [800..1027] MSA 1.780991 View MSA. No confident structure predictions are available.
    8 View Details [1028..1082] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.590503097160372 bayes_pls_golite062009
  • signal transducer activity
    		•  0.177373330518427 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.177373330518427 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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