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View Structure Prediction Details

Protein: SPT23
Organism: Saccharomyces cerevisiae
Length: 1082 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPT23.

Description E-value Query
Range
Subject
Range
SPT23_YEAST - Protein SPT23 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPT23 PE=1 SV=2
SPT23 - ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ...
0.0 [1..1082] [1..1082]
YEG5_SCHPO - Ankyrin and IPT/TIG repeat-containing protein C26H5.05 OS=Schizosaccharomyces pombe (strain 972 / AT...
SPAC26H5.05 - IPT /TIG ankyrin repeat protein
0.0 [37..1029] [155..1138]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [377..980] [71..714]
gi|25121952, gi|... - gi|25121952|ref|NP_733924.1| ankyrin 3, epithelial isoform a [Mus musculus], gi|18203774|gb|AAH21657...
0.0 [377..980] [54..697]

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Predicted Domain #1
Region A:
Residues: [1-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSGTGNVSS MLHSYSANIQ HNDGSPDLDL LESELLDIAL LNSGSSLQDP GLLSLNQEKM  60
   61 ITAGTTTPGK EDEGELRDDI ASLQGLLDRH VQFGRKLPLR TPYANPLDFI NINPQSLPLS 120
  121 LEIIGLPKVS RVETQMKLSF RIRNAHARKN FFIHLPSDCI AKDKFFTSSD DPTNLTIPNR 180
  181 D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [182-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INERTLFLDA FLLCASNNNS NNFKQTYVCN RCINREKRRA SRRKSGLNDN SIWQNNENKR  60
   61 AIIFNSKQLF IISNNGLSGN SNCINFDLPT RIVCYCRHHK ATNGFVVLFL LRDHNGDILA 120
  121 KTITDPIMIM DKKNASNTTT PTSTSNAQVS PMTNDTRSFS SPQSDLNFPS EFPLPSNSKN 180
  181 FVISTNCMLD SNCNNNNNDN DNKNNIKTNT AMMNNNRHFP SPNSSSEDSN HSFSDIHFSN 240
  241 NNDNNLHRSL DSWSSTGFNS SSNPALTTLT SDFSAASARH TGKRQRSVNE PFMSTPNTFS 300
  301 RLPQKFIDSS KDISNHNSV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [501-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVALNNKPSI QRVIPAQGSI NGGIEVTLLG SKFKQGLIIK FGENIALSSQ CWNESTMVTY  60
   61 LPPSSKPGPV LVTIVDPSET SMRNN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 12.236572
Match: PF01833
Description: IPT/TIG domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.60916417202222 bayes_pls_golite062009
transcription regulator activity 2.37103377984038 bayes_pls_golite062009
nucleic acid binding 1.8957142857582 bayes_pls_golite062009
DNA binding 1.78305438715057 bayes_pls_golite062009
transcription activator activity 1.6418915400902 bayes_pls_golite062009
transcription factor activity 1.2667825651547 bayes_pls_golite062009
transcription factor binding 1.06366405671195 bayes_pls_golite062009
sequence-specific DNA binding 0.949906091645366 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.590503097160372 bayes_pls_golite062009
signal transducer activity 0.177373330518427 bayes_pls_golite062009
molecular transducer activity 0.177373330518427 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [586-660]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSSVSTSNS TNDILHLNKY TGEKAIFTYV DDTDRQLIEL ALQIVGLKMN GKLEDARNIA  60
   61 KRIVGSDSSP SNNNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.228787
Match: 1iknD_
Description: I-kappa-B-alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [661-737]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLHSQNSSLN SYTNMMRNIN DEQLITEVIK SFKRNNNLST VNLSMCDVRG RTLLHLAAFN  60
   61 NWYSLVSLLI KYGSHLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.228787
Match: 1iknD_
Description: I-kappa-B-alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [738-799]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQDLFGFTPL HMACINGDLR IIRLLLECNV NIMKKTRNGF IAKQFFLMNY TVNKTRYSNY  60
   61 ET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.228787
Match: 1iknD_
Description: I-kappa-B-alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [800-1027]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLFDDILTRL TKNTTGSSDT QPFERNVSQS SFNSSLFDDD DADHDYVQER KYLLADSAAL  60
   61 APEQSNCNDN TSFSILDSDS GYDISDCESS SDEIALEFFN THKIKDFSSK PNEIPKTTKT 120
  121 SIEPDGSLWN RMLTRLNDEL PKYEDLFPKK PKNWELGSKS VEIGPDNSAQ MTVDDSQTSS 180
  181 EDDELEALQV GFNTIFSKKQ NFQNDKMLLF FWIPLTLVLL LCFTLSNL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1028-1082]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKDDDMFHNL SKIVQEYLRI GLAKVLLGNE RMKTSFKMQL SKFQNNNILN DMRVN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle