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Protein Overview: PEX8

General Information:
Name(s) found: PEX8 / YGR077C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 589 amino acids

    Gene Ontology:
    Cellular Component: peroxisomal membrane [IDALink to PubMed article]
    peroxisomal matrix [TAS]
    Biological Process: protein targeting to peroxisome [IMPLink to PubMed article]
    peroxisome organization [TAS]
    Molecular Function: peroxisome targeting sequence binding [NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDHDVEYLI TALSSETRIQ YDQRLLDEIA ANVVYYVPRV KSPDTLYRLV GALFRSQFIV  60
   61 QLPPLRLLHI VKDVFLWKLE VSEPTLPISK FYLVWNAVFE SHRATWNLSQ LMVLDGVLVT 120
  121 YPSFKQLNNA YFIDESSNKT ALYYRNWKLQ LFSPIWAQLW NTAIVRANLS IQHCLLIALA 180
  181 LLFNQSNRSA LLHGVDVSWN LVTEKLLDLL EEYVHGIVQP MEIFSTDSVL STNLNHLASC 240
  241 LTSSITRSNE ATLVNSVRKL ERICRYLSDT VASLKEQQLD FKFQNVFILI ILALKELSAM 300
  301 NMTILPNHKD TFYSMICLSL FHVHVLTQKI GTVGFPSYDY VYDNLVTYFI VMDDLSKITT 360
  361 VLELMKRNNT KQDPNKLVFY INFLNKITNY YGCRIRLPFI TEFIEPLLHF DVFFSGKTGN 420
  421 TLDIEIKESI HTLTITVLSI DSSYSSQVAQ WQVSRILVYL KMSMDQFIAG KLSANQILLI 480
  481 FGHLSTQLPS LHNYNKHLLR DSLHETYIRI VNVKNPEKKN VLIECLIVQI AFINNPHHLI 540
  541 GWLNICLQLI NTHNKKLLQQ LWEMVSSLES SLAIDWWYTT VLSSQSSKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) PEX13 PEX18 PEX5 PEX7 PEX8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 PEX8 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..298] deduced N/A No confident structure predictions are available.
    2 View Details [299..589] MSA 1.002893 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle