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Protein Overview: FAA2

General Information:
Name(s) found: FAA2 / YER015W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 744 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: lipid metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    N-terminal protein myristoylation [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: long-chain fatty acid-CoA ligase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPDYALTD LIESDPRFES LKTRLAGYTK GSDEYIEELY SQLPLTSYPR YKTFLKKQAV  60
   61 AISNPDNEAG FSSIYRSSLS SENLVSCVDK NLRTAYDHFM FSARRWPQRD CLGSRPIDKA 120
  121 TGTWEETFRF ESYSTVSKRC HNIGSGILSL VNTKRKRPLE ANDFVVAILS HNNPEWILTD 180
  181 LACQAYSLTN TALYETLGPN TSEYILNLTE APILIFAKSN MYHVLKMVPD MKFVNTLVCM 240
  241 DELTHDELRM LNESLLPVKC NSLNEKITFF SLEQVEQVGC FNKIPAIPPT PDSLYTISFT 300
  301 SGTTGLPKGV EMSHRNIASG IAFAFSTFRI PPDKRNQQLY DMCFLPLAHI FERMVIAYDL 360
  361 AIGFGIGFLH KPDPTVLVED LKILKPYAVA LVPRILTRFE AGIKNALDKS TVQRNVANTI 420
  421 LDSKSARFTA RGGPDKSIMN FLVYHRVLID KIRDSLGLSN NSFIITGSAP ISKDTLLFLR 480
  481 SALDIGIRQG YGLTETFAGV CLSEPFEKDV GSCGAIGISA ECRLKSVPEM GYHADKDLKG 540
  541 ELQIRGPQVF ERYFKNPNET SKAVDQDGWF STGDVAFIDG KGRISVIDRV KNFFKLAHGE 600
  601 YIAPEKIENI YLSSCPYITQ IFVFGDPLKT FLVGIVGVDV DAAQPILAAK HPEVKTWTKE 660
  661 VLVENLNRNK KLRKEFLNKI NKCTDGLQGF EKLHNIKVGL EPLTLEDDVV TPTFKIKRAK 720
  721 ASKFFKDTLD QLYAEGSLVK TEKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ARP4 FAA2 HFI1 RPO31 SPT7 STB4 SWC4 SWI5 TRA1
    View Details Qiu et al. (2008) FAA2 FAT1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [78..92]
    [119..131]
    [297..590]    		 PSI-BLAST 348.54902 Luciferase
    3 View Details [93..118]
    [132..296]
    [591..744]    		 PSI-BLAST 348.54902 Luciferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fatty acid ligase activity
    		•  4.83067429373059 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  4.72692389032116 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  3.91760861837127 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  3.07782226172454 bayes_pls_golite062009
  • CoA-ligase activity
    		•  2.9342873477171 bayes_pls_golite062009
  • lipid transporter activity
    		•  2.59608399999188 bayes_pls_golite062009
  • fatty acid transporter activity
    		•  2.59273384982209 bayes_pls_golite062009
  • ligase activity
    		•  2.49556073715112 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  2.48713831233526 bayes_pls_golite062009
  • luciferin monooxygenase activity
    		•  2.37933768142137 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • binding
    		•  1.5312519256537 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.51984692702316 bayes_pls_golite062009
  • transporter activity
    		•  1.29780964436121 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  1.18574343794772 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.12905679329698 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  1.11961482903654 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07143339827205 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.03753946113449 bayes_pls_golite062009
  • long-chain fatty acid transporter activity
    		•  0.914069798020245 bayes_pls_golite062009
  • hydrolase activity
    		•  0.793506623954019 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.75860693537743 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.54797726647835 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.340243634970102 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.320997446710099 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.251681382273558 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.225448500718996 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.216579620878492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.177812048124158 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.174283007890308 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.173963339749644 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.149232835558857 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0401881910649647 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0047964784091391 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle