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Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. Catalysis of the ligation of an acid and a thiol via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: acetate-CoA ligase activity
Acc: GO:0003987
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Synonyms:
  • short chain fatty acyl-CoA synthetase activity
  • acetyl coenzyme A synthetase activity
  • acetyl-activating enzyme activity
  • short-chain acyl-coenzyme A synthetase activity
  • acetic thiokinase activity
  • acetyl-CoA synthase activity
  • acetate thiokinase activity
  • acetate:CoA ligase (AMP-forming)
  • acetyl activating enzyme
  • acetyl-CoA synthetase activity
  • ACS
  • acetyl CoA synthase activity
  • acetyl-coenzyme A synthase activity
  • acetyl CoA ligase activity
  • acyl-activating enzyme activity
  • acetate to acetyl-CoA
Proteins in PDR annotated with:
   This term: 49 [Search]
   Term or descendants: 49 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003987 - acetate-CoA ligase activity (interactive image map)
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