YRC Public Data Repository - Protein Structure Prediction

Protein:	YNG2
Organism:	Saccharomyces cerevisiae
Length:	282 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YNG2.

Description	E-value	Query Range	Subject Range
gi\|6409280, gi\|6... - gi\|9712188\|dbj\|BAB08101.1\| p33ING1b [Homo sapiens], gi\|6409280\|gb\|AAF07921.1\|AF181850_1 p33ING1b [Ho... gi\|114650671 - gi\|114650671\|ref\|XP_001139907.1\| PREDICTED: inhibitor of growth family, member 1 isoform 3 [Pan trog...	5.0E-49	[6..278]	[15..266]
gi\|157169830 - gi\|157169830\|gb\|AAI52848.1\| Inhibitor of growth family, member 1 [synthetic construct] ING1_MOUSE - Inhibitor of growth protein 1 OS=Mus musculus GN=Ing1 PE=2 SV=1	1.0E-48	[6..278]	[15..266]
png1 - ING family homolog Png1 ING1_SCHPO - Chromatin modification-related protein png1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...	8.0E-47	[2..272]	[4..278]

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Predicted Domain #1

Region A:
Residues: [1-35]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPSLVLEQT IQDVSNLPSE FRYLLEEIGS NDLKL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [81-206]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLQREKCVLA NTALFLIARH LNKLEKNIAL LEEDGVLAPV EEDGDMDSAA EASRESSVVS  60
   61 NSSVKKRRAA SSSGSVPPTL KKKKTSRTSK LQNEIDVSSR EKSVTPVSPS IEKKIARTKE 120
  121 FKNSRN

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.77
Match:	2vsgA
Description:	Variant surface glycoprotein (N-terminal domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [36-80]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEEKKKYEQK ESQIHKFIRQ QGSIPKHPQE DGLDKEIKES LLKCQ

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.77
Match:	2vsgA
Description:	Variant surface glycoprotein (N-terminal domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [207-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKGQNGSPEN EEEDKTLYCF CQRVSFGEMV ACDGPNCKYE WFHYDCVNLK EPPKGTWYCP  60
   61 ECKIEMEKNK LKRKRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	1f62A_
Description:	Williams-Beuren syndrome transcription factor, WSTF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
lysine N-acetyltransferase activity	7.10262960897544	bayes_pls_golite062009
histone acetyltransferase activity	7.10262960897544	bayes_pls_golite062009
N-acetyltransferase activity	5.0952093808777	bayes_pls_golite062009
	4.93977737347339	bayes_pls_golite062009
	4.75659254650148	bayes_pls_golite062009
N-acyltransferase activity	4.73470737654883	bayes_pls_golite062009
acetyltransferase activity	4.29938591960121	bayes_pls_golite062009
acyltransferase activity	3.59302841227183	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.54892905221507	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.34035867339622	bayes_pls_golite062009
histone binding	3.01402804224903	bayes_pls_golite062009
binding	2.78627791259335	bayes_pls_golite062009
protein deacetylase activity	1.85191754801422	bayes_pls_golite062009
histone deacetylase activity	1.81121374048292	bayes_pls_golite062009
methylated histone residue binding	1.80051107279585	bayes_pls_golite062009
protein binding	1.6308789519356	bayes_pls_golite062009
DNA binding	1.25742999570208	bayes_pls_golite062009
nucleic acid binding	1.20287476673928	bayes_pls_golite062009
transcription regulator activity	1.08856770172893	bayes_pls_golite062009
chromatin binding	1.0360039180364	bayes_pls_golite062009
deacetylase activity	0.912057424750107	bayes_pls_golite062009
histone methyltransferase activity	0.476506467104495	bayes_pls_golite062009
protein kinase activity	0.405766438875014	bayes_pls_golite062009
nucleosome binding	0.252195940764881	bayes_pls_golite062009
transcription factor activity	0.157987030393304	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.14235705491362	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0901653273812402	bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific)	0.0490968711985191	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.040477854291574	bayes_pls_golite062009
kinase activity	0.00387875923819597	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: