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View Structure Prediction Details

Protein: SWR1
Organism: Saccharomyces cerevisiae
Length: 1514 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SWR1.

Description E-value Query
Range
Subject
Range
SWR1 - Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histo...
SWR1_YEAST - Helicase SWR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWR1 PE=1 SV=1
gi|151942310 - gi|151942310|gb|EDN60666.1| SWR1 complex component [Saccharomyces cerevisiae YJM789]
0.0 [1..1514] [1..1514]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [219..1509] [4..1280]
gi|11994423 - gi|11994423|dbj|BAB02425.1| helicase-like protein [Arabidopsis thaliana]
0.0 [211..1496] [3..1331]
gi|6330933 - gi|6330933|dbj|BAA86573.1| KIAA1259 protein [Homo sapiens]
0.0 [268..1436] [102..1296]
kis-PA - The gene kismet is referred to in FlyBase by the symbol Dmel\kis (CG3696, FBgn0086902). It is a prot...
0.0 [68..1180] [1497..2524]
gi|45384078, gi|... - gi|996020|emb|CAA62832.1| BRM protein [Gallus gallus], gi|45384078|ref|NP_990470.1| SWI/SNF related,...
0.0 [179..1156] [271..1196]
gi|85014495, gi|... - gi|85014495|ref|XP_955743.1| transcriptional activator [Encephalitozoon cuniculi GB-M1], gi|19171437...
gi|19173311 - ref|NP_597114.1| GLOBAL TRANSCRIPTIONAL ACTIVATOR (SNF2/RAD54 family) [Encephalitozoon cuniculi]
0.0 [480..1404] [57..883]

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Predicted Domain #1
Region A:
Residues: [1-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSRKSHAK DKKAGGEQDL ADLKFRYDLL TNELFHLREF VSLVDYDPTH FNDSESFQKF  60
   61 LRETHLSLEE RGEKFTDDVA KKGTNGDLTR RRRNLRTSTV VSSETTNEKK GDIELKLESI 120
  121 APLVRNKCEE LKYKLSDHSN RKSIVPQKRP IQHLKKREAA KSLKFKSERK ENPLPLHEHI 180
  181 AEERYDHIAK VEEPSEAFTI KCPSDDSSFE NTSEHYSDNF YFTTSSEEED IKKKRGRKKK 240
  241 KPRIKLVVHP PKQTITNPLH VVKPGYESLH EYIASFKSLE DDLTLEEYNK YIDEQRRLLS 300
  301 RLKKGIENGA LKYDKETDSL QPITSKEIKT IITYKPDPIS YFYKQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.154902
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [347-632]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLQIHTDHLI NQGIHMSKLF RSSTKARIAR AKKVSQMIEQ HFKHVAGAEE RKAKEEERHK  60
   61 KSLARFAVQA VKKRWNMAEK AYRILRKDEE EQLKRIEGKQ HLSKMLEKST QLLEAQLNQV 120
  121 NDDGRSSTPS SDSNDVLSES DDDMDDELST SSDEDEEVDA DVGLENSPAS TEATPTDESL 180
  181 NLIQLKEKYG HFNGSSTVYD SRNKDEKFPT LDKHESSSSE SSVMTGEESS IYSSSENESQ 240
  241 NENDRESDDK TPSVGLSALF GKGEESDGDL DLDDSEDFTV NSSSVE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [633-1005]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEELEKDQVD NSAATFERAG DFVHTQNENR DDIKDVEEDA ETKVQEEQLS VVDVPVPSLL  60
   61 RGNLRTYQKQ GLNWLASLYN NHTNGILADE MGLGKTIQTI SLLAYLACEK ENWGPHLIVV 120
  121 PTSVLLNWEM EFKRFAPGFK VLTYYGSPQQ RKEKRKGWNK PDAFHVCIVS YQLVVQDQHS 180
  181 FKRKRWQYMV LDEAHNIKNF RSTRWQALLN FNTQRRLLLT GTPLQNNLAE LWSLLYFLMP 240
  241 QTVIDGKKVS GFADLDAFQQ WFGRPVDKII ETGQNFGQDK ETKKTVAKLH QVLRPYLLRR 300
  301 LKADVEKQMP AKYEHIVYCK LSKRQRFLYD DFMSRAQTKA TLASGNFMSI VNCLMQLRKV 360
  361 CNHPNLFEVR PIL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 114.004365
Match: PF00176
Description: SNF2 family N-terminal domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.68677407235528 bayes_pls_golite062009
nucleic acid binding 2.55499128961037 bayes_pls_golite062009
telomeric DNA binding 2.51555240517937 bayes_pls_golite062009
single-stranded telomeric DNA binding 2.42617682290608 bayes_pls_golite062009
structural constituent of ribosome 2.05166830102408 bayes_pls_golite062009
structural molecule activity 1.88289765635623 bayes_pls_golite062009
DNA binding 1.82124247082886 bayes_pls_golite062009
structure-specific DNA binding 1.44779598506198 bayes_pls_golite062009
ribonuclease activity 1.29444332911502 bayes_pls_golite062009
single-stranded DNA binding 1.28974640221593 bayes_pls_golite062009
hydrolase activity 0.724860465280978 bayes_pls_golite062009
DNA-dependent ATPase activity 0.498105565279986 bayes_pls_golite062009
translation regulator activity 0.433181719163502 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.385829426544547 bayes_pls_golite062009
protein binding 0.360033745054291 bayes_pls_golite062009
exoribonuclease activity 0.249698955842391 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.227933240776321 bayes_pls_golite062009
chromatin binding 0.1876135725713 bayes_pls_golite062009
nuclease activity 0.1667307589287 bayes_pls_golite062009
translation initiation factor activity 0.12942560136182 bayes_pls_golite062009
telomerase inhibitor activity 0.111973370145519 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.0926650185896696 bayes_pls_golite062009
RNA polymerase activity 0.0926650185896696 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1006-1237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSFVLEHCVA SDYKDVERTL LKLFKKNNQV NRVDLDFLNL VFTLNDKDLT SYHAEEISKL  60
   61 TCVKNFVEEV NKLRETNKQL QEEFGEASFL NFQDANQYFK YSNKQKLEGT VDMLNFLKMV 120
  121 NKLRCDRRPI FGKNLIDLLT KDRRVKYDKS SIIDNELIKP LQTRVLDNRK IIDTFAVLTP 180
  181 SAVSLDMRKL ALGLNDDSSV GENTRLKVMQ NCFEVSNPLH QLQTKLTIAF PD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
DNA-dependent ATPase activity 2.58390156971125 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
binding 2.4974940028864 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.85030653553169 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.84811666933472 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.0904709750093 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
histone acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
nucleic acid binding 0.775560967092349 bayes_pls_golite062009
microtubule motor activity 0.60036517876321 bayes_pls_golite062009
pyrophosphatase activity 0.540750418412449 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.517457589081898 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
purine nucleotide binding 0.428373955572763 bayes_pls_golite062009
purine ribonucleotide binding 0.424644011903671 bayes_pls_golite062009
ribonucleotide binding 0.424583288440993 bayes_pls_golite062009
nucleotide binding 0.422354428195324 bayes_pls_golite062009
protein binding 0.378225828131122 bayes_pls_golite062009
DNA helicase activity 0.3665939534705 bayes_pls_golite062009
helicase activity 0.243380876721902 bayes_pls_golite062009
DNA binding 0.226110787229935 bayes_pls_golite062009
ATP binding 0.04834397972685 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0315266818880198 bayes_pls_golite062009
adenyl ribonucleotide binding 0.0149501427627318 bayes_pls_golite062009
structural constituent of ribosome 0.0102645529518819 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009
adenyl nucleotide binding 0.00365326483311895 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1238-1360]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSLLQYDCGK LQKLAILLQQ LKDNGHRALI FTQMTKVLDV LEQFLNYHGY LYMRLDGATK  60
   61 IEDRQILTER FNTDSRITVF ILSSRSGGLG INLTGADTVI FYDSDWNPAM DKQCQDRCHR 120
  121 IGQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 22.031517
Match: PF00271
Description: Helicase conserved C-terminal domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1361-1514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRDVHIYRFV SEHTIESNIL KKANQKRQLD NVVIQEGDFT TDYFSKLSVR DLLGSELPEN  60
   61 ASGGDKPLIA DADVAAKDPR QLERLLAQAE DEDDVKAANL AMREVEIDND DFDESTEKKA 120
  121 ANEEEENHAE LDEYEGTAHV DEYMIRFIAN GYYY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle