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Protein Overview: CPR1

General Information:
Name(s) found: CPR1 / YDR155C [SGD]
Description(s) found:
Found 43 descriptions.
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  • Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 162 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    histone deacetylase complex [IPILink to PubMed articleLink to PubMed article]
    Biological Process: ascospore formation [IMPLink to PubMed article]
    protein metabolic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVYFDVEA DGQPIGRVVF KLYNDIVPKT AENFRALCTG EKGFGYAGSP FHRVIPDFML  60
   61 QGGDFTAGNG TGGKSIYGGK FPDENFKKHH DRPGLLSMAN AGPNTNGSQF FITTVPCPWL 120
  121 DGKHVVFGEV VDGYDIVKKV ESLGSPSGAT KARIVVAKSG EL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) COF1 CPR1 EFB1 HOS2 HOS4 HYP2 SET3 SIF2 SNT1 SOD1 SSZ1
    View Details Krogan NJ, et al. (2006) CPR1 ECM38
    View Details Gavin AC, et al. (2006) CPR1 HOS2 HOS4 SET3 SIF2 SNT1
    View Details Gavin AC, et al. (2002) CPR1 HHF1, HHF2 HOS2 HOS4 KAP95 RVB2 SET3 SIF2 SNF2 SNT1
    View Details Ho Y, et al. (2002) AAT2 ABP1 ACH1 ACO1 ACS2 ADH2 ADH4 AFR1 AGX1 AHA1 AHP1 AIM21 ALA1 AMS1 APP1 ARC1 ARF1 ARG4 ATP3 BBC1 BIK1 BUD13 BUD20 CAR2 CDC13 CDC15 CDC33 CDC53 CDC60 CIC1 CLU1 CMD1 CMK2 CMP2 COF1 COR1 CPR1 CPR3 CYR1 CYS4 DED81 DUG2 DUN1 DUT1 EDE1 EGD1 EHD3 ENP1 ERG10 ERG13 ERG20 ERG6 FOL2 FPR1 FRS2 FUM1 FYV8 GND1 GND2 GPI15 GRR1 GRS1 GRX1 GSY2 GUS1 HCH1 HEF3 HHF1, HHF2 HHT1, HHT2 HMO1 HOM2 HSH49 HSP12 HTB1 HTB2 HYP2 IGO1 ILS1 IPP1 IST3 KGD1 LAP4 LRO1 LSM2 LSP1 MAM33 MDH1 MET6 MGM101 MGT1 MIH1 MPC54 MRPS16 MYO2 MYO4 MYO5 NAS6 NTF2 OLA1 OYE2 PDC5 PDC6 PDX3 PFK1 PGM2 PIL1 POR1 PRM2 PRO1 PST2 QCR2 RAD1 RAD10 RLP24 RNR2 RSE1 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SHE3 SKP1 SMT3 SNU13 SOD1 SSZ1 SUI1 TEF4 TEM1 TFP1 THR4 THS1 TIF1, TIF2 TMA19 TMA29 TPS1 TRR1 TSA2 UBA1 UBI4 UTP20 VAS1 VMA4 VMA5 VPS13 WTM1 YDL124W YDR341C YFL006W YGR066C YNK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CPR1 Huh WK, et al. (2003)
    View Data CPR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] PSI-BLAST 633.9691 Cyclophilin (eukaryotic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.3775483906311 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.29026678196473 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • deacetylase activity
    		•  3.49940864924766 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.01511519120932 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • binding
    		•  1.46018233647024 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • hydrolase activity
    		•  0.493806105600863 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.408539130322443 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.322244688184474 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.286133802341887 bayes_pls_golite062009
  • histone binding
    		•  0.268719695649015 bayes_pls_golite062009
  • protein binding
    		•  0.130251391659493 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle