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Protein Overview: SMT3

General Information:
Name(s) found: SMT3 / YDR510W [SGD]
Description(s) found:
Found 40 descriptions.
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  • Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 101 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    septin ring [IDALink to PubMed articleLink to PubMed article]
    Biological Process: protein sumoylation [TASLink to PubMed article]
    Molecular Function: protein tag [IDALink to PubMed articleLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSEVNQEA KPEVKPEVKP ETHINLKVSD GSSEIFFKIK KTTPLRRLME AFAKRQGKEM  60
   61 DSLRFLYDGI RIQADQTPED LDMEDNDIIE AHREQIGGAT Y

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C
    View Details Ho Y, et al. (2002) CPR1 SMT3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SMT3 SLX5 2 Unpublished Fields Lab Data
    View Screen SMT3 UBC9 2 Uetz P, et al. (2000)
    View Screen NSE5 SMT3 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SMT3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] PSI-BLAST 487.69897 SUMO-1 (smt3 homologue)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SUMO ligase activity
    		•  3.84399877513864 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.71144418714309 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.89535476350045 bayes_pls_golite062009
  • binding
    		•  2.786655943372 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.72499875710239 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21955949922709 bayes_pls_golite062009
  • protein tag
    		•  2.15059229834935 bayes_pls_golite062009
  • protein binding
    		•  1.86841453215444 bayes_pls_golite062009
  • DNA binding
    		•  1.86539227646379 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.73491621577173 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.69351004422121 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.30022874337859 bayes_pls_golite062009
  • tubulin binding
    		•  0.984710328639471 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.753885975469065 bayes_pls_golite062009
  • microtubule binding
    		•  0.721760846967789 bayes_pls_golite062009
  • signal transducer activity
    		•  0.65988002090613 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.65988002090613 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.599634454232833 bayes_pls_golite062009
  • structural molecule activity
    		•  0.576819726104993 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.570143717979967 bayes_pls_golite062009
  • protein kinase activity
    		•  0.325253662829604 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.249928925871521 bayes_pls_golite062009
  • enzyme binding
    		•  0.240262781026149 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0871262449740772 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0816453389356582 bayes_pls_golite062009
  • kinase activity
    		•  0.0363894273406812 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle