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Protein Overview: HCH1

General Information:
Name(s) found: HCH1 / YNL281W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 153 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    protein folding [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    response to stress [IEPLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: chaperone binding [IDALink to PubMed article]
    chaperone activator activity [IDALink to PubMed article][IPILink to PubMed article]
    ATPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVLNPNNWH WVDKNTLPWS KDYLNGKLTS LSTVSSDGKS KIELTQVSSI TGDSNVSQRK  60
   61 GKPICYFDLQ LSMNVKVTNL DTNKDDEDDD GILADGKLEI PEFMHDESDI PILSQGFDAF 120
  121 DGLVRSEFVP KVVETLLKYQ DDLIKEHSKD IQV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HCH1 HOR2 LIF1 PIG2 YBR139W YKL069W
    View Details Ho Y, et al. (2002) CMD1 CMK2 CMP2 COF1 CPR1 EDE1 HCH1 HYP2 ILS1 IPP1 MYO2 MYO4 MYO5 PGM2 PST2 SHE3 SOD1 UBA1 VAS1 VPS13 YNK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HCH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • chaperone binding
    		•  2.87169826684641 bayes_pls_golite062009
  • ATPase regulator activity
    		•  2.31076586548557 bayes_pls_golite062009
  • binding
    		•  2.05200237600398 bayes_pls_golite062009
  • ATPase activator activity
    		•  1.99816875782377 bayes_pls_golite062009
  • protein binding
    		•  1.12549021331477 bayes_pls_golite062009
  • heat shock protein binding
    		•  0.760536282739404 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle