YRC Public Data Repository - Protein Structure Prediction

Protein:	HCH1
Organism:	Saccharomyces cerevisiae
Length:	153 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HCH1.

Description	E-value	Query Range	Subject Range
HCH1_YEAST - Hsp90 co-chaperone HCH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HCH1 PE=1 SV=1 HCH1 - Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally iden... gi\|190409250 - gi\|190409250\|gb\|EDV12515.1\| Hsp90 co-chaperone HCH1 [Saccharomyces cerevisiae RM11-1a]	6.0E-52	[1..153]	[1..153]
YNY8_SCHPO - Uncharacterized protein C1711.08 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC1711.... SPBC1711.08 - chaperone activator Aha1	3.0E-47	[4..151]	[6..150]
gi\|3850126 - gi\|3850126\|emb\|CAA21927.1\| conserved hypothetical protein [Candida albicans]	1.0E-46	[1..152]	[1..147]
AHSA1 - AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	8.0E-43	[5..151]	[21..163]
AHSA1_MOUSE - Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus GN=Ahsa1 PE=1 SV=2	2.0E-40	[5..151]	[21..163]
CE07817 - status:Confirmed UniProt:Q93168 protein_id:CAB02710.1	9.0E-39	[5..151]	[21..165]
gi\|21593383, gi\|... - gi\|21593383\|gb\|AAM65332.1\| unknown [Arabidopsis thaliana], gi\|18399461\|ref\|NP_566410.1\| Aha1 domain-...	7.0E-33	[5..141]	[21..161]

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Predicted Domain #1

Region A:
Residues: [1-153]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVLNPNNWH WVDKNTLPWS KDYLNGKLTS LSTVSSDGKS KIELTQVSSI TGDSNVSQRK  60
   61 GKPICYFDLQ LSMNVKVTNL DTNKDDEDDD GILADGKLEI PEFMHDESDI PILSQGFDAF 120
  121 DGLVRSEFVP KVVETLLKYQ DDLIKEHSKD IQV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
chaperone binding	2.87169826684641	bayes_pls_golite062009
ATPase regulator activity	2.31076586548557	bayes_pls_golite062009
binding	2.05200237600398	bayes_pls_golite062009
ATPase activator activity	1.99816875782377	bayes_pls_golite062009
protein binding	1.12549021331477	bayes_pls_golite062009
heat shock protein binding	0.760536282739404	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: