YRC Public Data Repository - Protein Structure Prediction

Protein:	HCH1
Organism:	Saccharomyces cerevisiae
Length:	153 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HCH1.

Description	E-value	Query Range	Subject Range
HCH1_YEAST - Hsp90 co-chaperone HCH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HCH1 PE=1 SV=1 HCH1 - Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally iden... gi\|190409250 - gi\|190409250\|gb\|EDV12515.1\| Hsp90 co-chaperone HCH1 [Saccharomyces cerevisiae RM11-1a]	6.0E-52	[1..153]	[1..153]
YNY8_SCHPO - Uncharacterized protein C1711.08 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC1711.... SPBC1711.08 - chaperone activator Aha1	3.0E-47	[4..151]	[6..150]
gi\|3850126 - gi\|3850126\|emb\|CAA21927.1\| conserved hypothetical protein [Candida albicans]	1.0E-46	[1..152]	[1..147]
AHSA1 - AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	8.0E-43	[5..151]	[21..163]
AHSA1_MOUSE - Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus GN=Ahsa1 PE=1 SV=2	2.0E-40	[5..151]	[21..163]
CE07817 - status:Confirmed UniProt:Q93168 protein_id:CAB02710.1	9.0E-39	[5..151]	[21..165]
gi\|21593383, gi\|... - gi\|21593383\|gb\|AAM65332.1\| unknown [Arabidopsis thaliana], gi\|18399461\|ref\|NP_566410.1\| Aha1 domain-...	7.0E-33	[5..141]	[21..161]

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Predicted Domain #1

Region A:
Residues: [1-153]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVLNPNNWH WVDKNTLPWS KDYLNGKLTS LSTVSSDGKS KIELTQVSSI TGDSNVSQRK  60
   61 GKPICYFDLQ LSMNVKVTNL DTNKDDEDDD GILADGKLEI PEFMHDESDI PILSQGFDAF 120
  121 DGLVRSEFVP KVVETLLKYQ DDLIKEHSKD IQV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
chaperone binding	2.87169826684641	bayes_pls_golite062009
ATPase regulator activity	2.31076586548557	bayes_pls_golite062009
binding	2.05200237600398	bayes_pls_golite062009
ATPase activator activity	1.99816875782377	bayes_pls_golite062009
protein binding	1.12549021331477	bayes_pls_golite062009
heat shock protein binding	0.760536282739404	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: