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Protein Overview: ECM38

General Information:
Name(s) found: ECM38 / YLR299W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 660 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: glutathione catabolic process [TASLink to PubMed article]
    Molecular Function: protein-glutamine gamma-glutamyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLCNRKVPK TLNTCFILHI FTLLTLGVLV SGMPSKMVSF ASQETLQRIN NLLRGSANRD  60
   61 VDIIAEYLKK DDDDDGGDKD HHNIDIDPLP RRPSLTPDRQ LLKVGLHGAI SSDLEVCSNL 120
  121 TINEVLLKFP GSNAADAAVT QALCKGMVNF FNSGIGGGGY VVFSGKDDED HLSIDFREKA 180
  181 PMDSHKFMFE NCSLCSKIGG LAVGVPGELM GLYRLFKERG SGQVDWRDLI EPVAKLGSVG 240
  241 WQIGEALGAT LELYEDVFLT LKEDWSFVLN STHDGVLKEG DWIKRPALSN MLMELAKNGS 300
  301 VAPFYDPDHW IAKSMIDTVA KYNGIMNLQD VSSYDVHVTK PLSMKIRKGA NFIPDNDMTV 360
  361 LTSSGSSSGA ALLAALRIMD NFQNQEGGDY EKETTYHLLE SMKWMASARS RLGDFEGEAL 420
  421 PKHIEEVLDP EWALKAVKSI KRNSQDGNFK TLENWTLYDP AYDINNPHGT AHFSIVDSHG 480
  481 NAVSLTTTIN LLFGSLVHDP KTGVIFNNEM DDFAQFNKSN SFELAPSIYN FPEPGKRPLS 540
  541 STAPTIVLSE LGIPDLVVGA SGGSRITTSV LQTIVRTYWY NMPILETIAY PRIHHQLLPD 600
  601 RIELESFPMI GKAVLSTLKE MGYTMKEVFP KSVVNAIRNV RGEWHAVSDY WRKRGISSVY 660
  661

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CPR1 ECM38

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #15 Mitotic 2nd-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ECM38 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..274] ORFEUS 8.46 Monomeric isocitrate dehydrogenase
    2 View Details [275..440] ORFEUS 8.46 Monomeric isocitrate dehydrogenase
    3 View Details [441..660] ORFEUS 7.75 Glycosylasparaginase (aspartylglucosaminidase, AGA)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • peptidase activity
    		•  2.36621306284094 bayes_pls_golite062009
  • hydrolase activity
    		•  2.34679426809641 bayes_pls_golite062009
  • gamma-glutamyltransferase activity
    		•  2.21821955124661 bayes_pls_golite062009
  • transferase activity, transferring amino-acyl groups
    		•  2.09518916120707 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.05417833810024 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.98364900190373 bayes_pls_golite062009
  • catalytic activity
    		•  1.1186710875396 bayes_pls_golite062009
  • binding
    		•  0.834657684213424 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.050580993362788 bayes_pls_golite062009
  • protein binding
    		•  0.0330711408938561 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0152030928962795 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.00707009173217921 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.00389570308650089 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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