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Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein-glutamine gamma-glutamyltransferase activity
Acc: GO:0003810
Aspect: Molecular Function
Desc: Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
Synonyms:
  • glutaminylpeptide gamma-glutamyltransferase activity
  • TGase activity
  • fibrinoligase activity
  • polyamine transglutaminase activity
  • factor XIIIa
  • protein-glutamine:amine gamma-glutamyltransferase
  • R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
  • fibrin stabilizing factor
  • tissue transglutaminase
  • transglutaminase activity
Proteins in PDR annotated with:
   This term: 32 [Search]
   Term or descendants: 32 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003810 - protein-glutamine gamma-glutamyltransferase activity (interactive image map)
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