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Protein Overview: EFB1

General Information:
Name(s) found: EFB1 / YAL003W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 206 amino acids

    Gene Ontology:
    Cellular Component: ribosome [TASLink to PubMed article]
    eukaryotic translation elongation factor 1 complex [IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: translational elongation [TASLink to PubMed article]
    Molecular Function: translation elongation factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTDFSKIE TLKQLNASLA DKSYIEGTAV SQADVTVFKA FQSAYPEFSR WFNHIASKAD  60
   61 EFDSFPAASA AAAEEEEDDD VDLFGSDDEE ADAEAEKLKA ERIAAYNAKK AAKPAKPAAK 120
  121 SIVTLDVKPW DDETNLEEMV ANVKAIEMEG LTWGAHQFIP IGFGIKKLQI NCVVEDDKVS 180
  181 LDDLQQSIEE DEDHVQSTDI AAMQKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABP1 CAM1 CPR1 EFB1 GUS1 HSP104 HXK1 HYP2 RPL40B, RPL40A SSB2 SSZ1 TEF4 YEF3 ZUO1
    View Details (MIPS) Mewes HW, et al. (2004) CAM1 EFB1 HBS1 TEF1, TEF2 TEF4
    View Details Gavin AC, et al. (2006) CAM1 EFB1 TEF1, TEF2
    View Details Gavin AC, et al. (2002) CAM1 EFB1 FAP1 GFA1 GUS1 ILV1 KAP123 MGA2 NEW1 OLA1 SBP1 SEC27 TEF1, TEF2 TEF4
    View Details Ho Y, et al. (2002) ADK1 CDC33 DUG2 EFB1 SEC53 TEM1 VMA5 YHB1
    View Details Qiu et al. (2008) EFB1 TEF1, TEF2 TEF4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run ASF1 sample 3928 - Asf1-S-TEV-ZZ (in hir3delta mutant) Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] PSI-BLAST 5.69897 Class delta GST
    2 View Details [88..206] PSI-BLAST 464.741366 Guanine nucleotide exchange factor (GEF) domain from elongation factor-1 beta

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.65945313523198 bayes_pls_golite062009
  • binding
    		•  1.45526122320486 bayes_pls_golite062009
  • transferase activity
    		•  1.05573069897577 bayes_pls_golite062009
  • catalytic activity
    		•  0.963623964325467 bayes_pls_golite062009
  • receptor binding
    		•  0.490857233487879 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.46030380837916 bayes_pls_golite062009
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
    		•  0.44372379417457 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.385619646192102 bayes_pls_golite062009
  • RNA binding
    		•  0.382017633056715 bayes_pls_golite062009
  • peptide binding
    		•  0.22963019108532 bayes_pls_golite062009
  • glutathione transferase activity
    		•  0.20688408808374 bayes_pls_golite062009
  • DNA binding
    		•  0.175092771820973 bayes_pls_golite062009
    2
    Term Confidence Notes
  • translation elongation factor activity
    		•  12.3173391557088 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  7.81664120156021 bayes_pls_golite062009
  • translation regulator activity
    		•  7.77673515271111 bayes_pls_golite062009
  • binding
    		•  2.83703195704118 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.61354904861592 bayes_pls_golite062009
  • actin binding
    		•  1.90340345597574 bayes_pls_golite062009
  • protein binding
    		•  1.74079757896683 bayes_pls_golite062009
  • signal transducer activity
    		•  1.65423237700268 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.65423237700268 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.63487486759233 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.669814437561164 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.651746786837234 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.555069882515023 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.260738180200771 bayes_pls_golite062009
  • actin monomer binding
    		•  0.2298282502586 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle