YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: ACS2

General Information:
Name(s) found: ACS2 / YLR153C [SGD]
Description(s) found:
Found 30 descriptions.
SHOW ALL
  • Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 683 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed articleLink to PubMed article]
    Biological Process: acetyl-CoA biosynthetic process [IDALink to PubMed article]
    histone acetylation [IMPLink to PubMed article]
    Molecular Function: acetate-CoA ligase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIKEHKVVY EAHNVKALKA PQHFYNSQPG KGYVTDMQHY QEMYQQSINE PEKFFDKMAK  60
   61 EYLHWDAPYT KVQSGSLNNG DVAWFLNGKL NASYNCVDRH AFANPDKPAL IYEADDESDN 120
  121 KIITFGELLR KVSQIAGVLK SWGVKKGDTV AIYLPMIPEA VIAMLAVARI GAIHSVVFAG 180
  181 FSAGSLKDRV VDANSKVVIT CDEGKRGGKT INTKKIVDEG LNGVDLVSRI LVFQRTGTEG 240
  241 IPMKAGRDYW WHEEAAKQRT YLPPVSCDAE DPLFLLYTSG STGSPKGVVH TTGGYLLGAA 300
  301 LTTRYVFDIH PEDVLFTAGD VGWITGHTYA LYGPLTLGTA SIIFESTPAY PDYGRYWRII 360
  361 QRHKATHFYV APTALRLIKR VGEAEIAKYD TSSLRVLGSV GEPISPDLWE WYHEKVGNKN 420
  421 CVICDTMWQT ESGSHLIAPL AGAVPTKPGS ATVPFFGINA CIIDPVTGVE LEGNDVEGVL 480
  481 AVKSPWPSMA RSVWNHHDRY MDTYLKPYPG HYFTGDGAGR DHDGYYWIRG RVDDVVNVSG 540
  541 HRLSTSEIEA SISNHENVSE AAVVGIPDEL TGQTVVAYVS LKDGYLQNNA TEGDAEHITP 600
  601 DNLRRELILQ VRGEIGPFAS PKTIILVRDL PRTRSGKIMR RVLRKVASNE AEQLGDLTTL 660
  661 ANPEVVPAII SAVENQFFSQ KKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACS2 TKL1 TKL2
    View Details Ho Y, et al. (2002) AAT2 ACS2 ADE3 ADE6 ADH4 ADO1 ALA1 APE2 ARA1 ARG4 BAT1 CAR2 CDC10 CDC60 CLU1 CPR1 CYS3 DED81 DLD3 DPS1 DUG1 ENP1 ERG10 ERG20 FUM1 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 ILV3 IMD3 KRS1 LSP1 MDH3 MPC54 NAS6 OLA1 PAB1 PDC5 PFK2 PGM2 PMI40 PRP6 RHO1 SAC6 SCP160 SOD1 SSZ1 SUI1 THR4 TPS1 TRR1 UBA1 WTM1 YDL124W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ACS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79]
    [345..531]    		 PSI-BLAST 269.218487 Phenylalanine activating domain of gramicidin synthetase 1
    2 View Details [80..127]
    [280..344]
    [532..683]    		 PSI-BLAST 269.218487 Phenylalanine activating domain of gramicidin synthetase 1
    3 View Details [128..279] PSI-BLAST 269.218487 Phenylalanine activating domain of gramicidin synthetase 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming carbon-sulfur bonds
    		•  5.10123876514454 bayes_pls_golite062009
  • fatty acid ligase activity
    		•  4.83067429373059 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  4.72692389032116 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  4.48129067128523 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  4.28278725989432 bayes_pls_golite062009
  • CoA-ligase activity
    		•  4.12850865352867 bayes_pls_golite062009
  • Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
    		•  2.74744781333102 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
    		•  2.74744781333102 bayes_pls_golite062009
  • luciferin monooxygenase activity
    		•  2.67396462766343 bayes_pls_golite062009
  • ligase activity
    		•  2.49556073715112 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31193176808353 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • binding
    		•  1.5312519256537 bayes_pls_golite062009
  • transporter activity
    		•  1.29780964436121 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.2638869228049 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07143339827205 bayes_pls_golite062009
  • acetoacetate-CoA ligase activity
    		•  1.03788694975627 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.03753946113449 bayes_pls_golite062009
  • protein binding
    		•  0.985225190358794 bayes_pls_golite062009
  • AMP binding
    		•  0.778227294974491 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.54797726647835 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.519946577969422 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.500908589473269 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.464663038956639 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.398310577427897 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.251681382273558 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.225448500718996 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.216579620878492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.177812048124158 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.174283007890308 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.173963339749644 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0401881910649647 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0047964784091391 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle