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Protein Overview: DPS1

General Information:
Name(s) found: DPS1 / YLL018C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 557 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISSLink to PubMed article]
    Biological Process: translation [ISSLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]
    aspartate-tRNA ligase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQDENIVKA VEESAEPAQV ILGEDGKPLS KKALKKLQKE QEKQRKKEER ALQLEAEREA  60
   61 REKKAAAEDT AKDNYGKLPL IQSRDSDRTG QKRVKFVDLD EAKDSDKEVL FRARVHNTRQ 120
  121 QGATLAFLTL RQQASLIQGL VKANKEGTIS KNMVKWAGSL NLESIVLVRG IVKKVDEPIK 180
  181 SATVQNLEIH ITKIYTISET PEALPILLED ASRSEAEAEA AGLPVVNLDT RLDYRVIDLR 240
  241 TVTNQAIFRI QAGVCELFRE YLATKKFTEV HTPKLLGAPS EGGSSVFEVT YFKGKAYLAQ 300
  301 SPQFNKQQLI VADFERVYEI GPVFRAENSN THRHMTEFTG LDMEMAFEEH YHEVLDTLSE 360
  361 LFVFIFSELP KRFAHEIELV RKQYPVEEFK LPKDGKMVRL TYKEGIEMLR AAGKEIGDFE 420
  421 DLSTENEKFL GKLVRDKYDT DFYILDKFPL EIRPFYTMPD PANPKYSNSY DFFMRGEEIL 480
  481 SGAQRIHDHA LLQERMKAHG LSPEDPGLKD YCDGFSYGCP PHAGGGIGLE RVVMFYLDLK 540
  541 NIRRASLFPR DPKRLRP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DPS1 RAD1 RAD10 SAW1
    View Details Gavin AC, et al. (2006) ADE3 DPS1 ILV1 RPL18A, RPL18B SAR1 TDH1 YDR341C YNK1
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 BAT1 CDC10 CLU1 CYS3 DED81 DPS1 ENP1 ERG10 ERG20 GCY1 GPH1 GRS1 GSP1 GSP2 HOM2 HRP1 HYP2 ILS1 IMD3 KAP104 KRS1 LSP1 MDH3 MRT4 NAB2 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 SAC6 SCP160 SOD1 SSZ1 THR4 TRR1 UBA1 YDL063C YDL124W YNL035C YRB1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DPS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] PSI-BLAST 10138.0 Aspartyl-tRNA synthetase (AspRS)
    2 View Details [211..557] PSI-BLAST 10138.0 Aspartyl-tRNA synthetase (AspRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • lysine-tRNA ligase activity
    		•  11.0047124677093 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  5.29805946490109 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  3.80084837437429 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  3.4145644216516 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.90150581291897 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.61548498770105 bayes_pls_golite062009
  • structural molecule activity
    		•  2.54582212334303 bayes_pls_golite062009
  • proline-tRNA ligase activity
    		•  2.52223115725965 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.07594942154162 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67362693618722 bayes_pls_golite062009
  • binding
    		•  1.54403712698597 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48056625237411 bayes_pls_golite062009
  • DNA binding
    		•  1.44496421928708 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • transcription factor activity
    		•  0.825973629967327 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.77755643935497 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.702449673647117 bayes_pls_golite062009
  • nuclease activity
    		•  0.29926900436997 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle