Protein Overview: PRP6

General Information:
Name(s) found:	PRP6 / YBR055C [SGD]
Description(s) found: Found 27 descriptions. SHOW ALL	Splicing factor, component of the U4/U6-U5 snRNP complex [SGD]
Organism:	Saccharomyces cerevisiae
Length:	899 amino acids
Gene Ontology:
Cellular Component:	U4/U6 x U5 tri-snRNP complex [IDA][IPI]
Biological Process:	nuclear mRNA splicing, via spliceosome [IPI]
Molecular Function:	binding [IEA] molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERPSFLDQE PPAGYVPGIG RGATGFSTKE KQVVSNDDKG RRIPKRYREN LNNHLQSQPK  60
   61 DDEDDEAANV FKTLELKLAQ KKKKRANEKD DDNSVDSSNV KRQFADLKES LAAVTESEWM 120
  121 DIPDATDFTR RNKRNRIQEQ LNRKTYAAPD SLIPGNVDLN KLTEEREKLL QSQIDENLAQ 180
  181 LTKNASNPIQ VNKPNAATDA LSYLKDLEND RVNSLSDATL EDLQKMRTIL KSYRKADPTN 240
  241 PQGWIASARL EEKARKFSVA KKIIENGCQE CPRSSDIWLE NIRLHESDVH YCKTLVATAI 300
  301 NFNPTSPLLW FKAIDLESTT VNKYRVVRKA LQEIPRDEGL WKLAVSFEAD KAQVIKMLEK 360
  361 ATQFIPQSMD LLTAYTNLQS YHNAKMTLNS FRKILPQEPE IWIISTLLEE RNNPDIPVDK 420
  421 LVSLLKEGLL ELSKNGYKAT LSAWLKRAEA LNDAPNSNLT CQAIVYAILE WLRESGEYES 480
  481 ELNNVDQILE KMPHSKVQIA VLKKLIQWDP CDTVLWSRLK MATESYHKIE ELLAFFQELL 540
  541 FQTKNSDDIR ANMREKSPGL LMMYVSEYWK AQKGDTRQTL VLIDQIIDFA PHNLDLRFFK 600
  601 IKLLGRSLQL DELRDFFQQT FSSLEDFKIS GTERLYYKYV NFLRYQDLNE EAIKFLNERC 660
  661 LKSFPICHKF FLQLGQIYHS MGNIEMSRET YLSGTRLVPN CPLLWVSLSK IDEIDLKNPV 720
  721 RARSILDRGL LKNPDDVLFY IAKIQMEIRL GNLDQAELLV TQALQKFPSN ALLWVEQIKL 780
  781 FKHGNKSSLK KTIFQDALRR TQNDHRVLLE IGVSFYAEAQ YETSLKWLER ALKKCSRYGD 840
  841 TWVWLFRTYA RLGKDTVDLY NMFDQCEPTY GPEWIAASKN VKMQYCTPRE ILLRLMNDK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		AAR2 BRR2 CSN12 CUS1 DIB1 HSH155 LEA1 LSM1 LSM2 LSM4 LSM6 MSL1 PAT1 PRP11 PRP19 PRP21 PRP24 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP6 PRP8 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SME1 SNU114 SNU23 SNU66 SNU71 SPP381 SPP382
View Details	(MIPS) Mewes HW, et al. (2004)		AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
View Details	Krogan NJ, et al. (2006)		AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
View Details	Gavin AC, et al. (2006)		BRR2 CUS1 LEA1 PRP21 PRP3 PRP31 PRP4 PRP6 PRP8 PRP9 SMB1 SNU114 SNU23 SNU66 SPP381
View Details	Gavin AC, et al. (2002)		AAR2 ASC1 BRR1 BUD31 CBC2 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DCP2 DHH1 DIB1 ECM2 ERB1 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 KRS1 LEA1 LIN1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM7 NAM8 NOG2 NOP1 NPL3 NUG1 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SQS1 SRB2 SRO9 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
View Details	Ho Y, et al. (2002)		ACS2 ADE17 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 BAT1 BRR2 CDC10 CLU1 CYS3 DED81 DPS1 ERG10 ERG20 GCY1 GPH1 GRS1 HOM2 HSL7 HYP2 ILS1 IMD3 KRS1 LSP1 MDH1 MDH3 OLA1 PAB1 PFK2 PGM2 PMI40 PRP3 PRP31 PRP4 PRP6 SAC6 SCP160 SOD1 SSZ1 THR4 TPS1 TRR1 UBA1 YDL124W
View Details	Qiu et al. (2008)		AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC2 CWC22 CWC23 DIB1 ECM2 HSH155 HSH49 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	HSL7	No Comments	McCusker D, et al (2007)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PRP6	DIB1	2	Uetz P, et al. (2000)
View Screen	SPP382	PRP6	2	Hazbun TR, et al. (2003)
View Screen	PRP6	UBC9	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PRP6	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..123]	MSA	2.07897	View MSA. No confident structure predictions are available.
2	View Details	[124..274]	ab initio	14.34	No description for 1qqeA was found.
3	View Details	[275..436]	ab initio	14.34	No description for 1qqeA was found.
4	View Details	[437..559]	PSI-BLAST	3.522879	Transcription factor MalT domain III
5	View Details	[560..766]	PSI-BLAST	3.522879	Transcription factor MalT domain III
6	View Details	[767..899]	PSI-BLAST	35.30103	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2