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Protein Overview: YHC1

General Information:
Name(s) found: YHC1 / YLR298C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 231 amino acids

    Gene Ontology:
    Cellular Component: commitment complex [IPILink to PubMed article]
    U1 snRNP [IDALink to PubMed articleLink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IPILink to PubMed article]
    Molecular Function: mRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRYYCEYCH SYLTHDTLSV RKSHLVGKNH LRITADYYRN KARDIINKHN HKRRHIGKRG  60
   61 RKERENSSQN ETLKVTCLSN KEKRHIMHVK KMNQKELAQT SIDTLKLLYD GSPGYSKVFV 120
  121 DANRFDIGDL VKASKLPQRA NEKSAHHSFK QTSRSRDETC ESNPFPRLNN PKKLEPPKIL 180
  181 SQWSNTIPKT SIFYSVDILQ TTIKESKKRM HSDGIRKPSS ANGYKRRRYG N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LUC7 MUD1 NAM8 PRP11 PRP39 PRP40 PRP42 SMB1 SMD1 SMD2 SMD3 SNP1 SNU56 SNU71 STO1 YHC1
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Gavin AC, et al. (2006) LUC7 MUD1 NAM8 PRP39 PRP40 PRP42 SNP1 SNU56 SNU71 YHC1
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC21 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 HSH155 HSH49 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM7 LSM8 LUC7 MAK5 MSL1 MSL5 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SYF1 SYF2 YHC1 YJU2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data YHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] MSA 11.012992 View MSA. No confident structure predictions are available.
    2 View Details [70..231] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • U1 snRNA binding
    		•  4.35911393951689 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.60566283434269 bayes_pls_golite062009
  • DNA binding
    		•  3.55661236227495 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.48507500696529 bayes_pls_golite062009
  • snRNA binding
    		•  3.38579636849163 bayes_pls_golite062009
  • RNA binding
    		•  3.1651307444578 bayes_pls_golite062009
  • transcription factor activity
    		•  2.66585743129629 bayes_pls_golite062009
  • binding
    		•  2.51459778938853 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.8286807075508 bayes_pls_golite062009
  • transcription activator activity
    		•  1.42518458564872 bayes_pls_golite062009
  • mRNA binding
    		•  1.30742677372942 bayes_pls_golite062009
  • chromatin binding
    		•  0.89589330553881 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.8936929860974 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.882178479686399 bayes_pls_golite062009
  • transcription factor binding
    		•  0.67452735768188 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.47352407708364 bayes_pls_golite062009
  • protein binding
    		•  0.308413944574415 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.26487559807277 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.240825841910931 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0129353639725593 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle