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Protein Overview: PRP9

General Information:
Name(s) found: PRP9 / YDL030W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 530 amino acids

    Gene Ontology:
    Cellular Component: U2 snRNP [IDALink to PubMed articleLink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IDALink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLLETRRSL LEEMEIIENA IAERIQRNPE LYYHYIQESS KVFPDTKLPR SSLIAENKIY  60
   61 KFKKVKRKRK QIILQQHEIN IFLRDYQEKQ QTFNKINRPE ETQEDDKDLP NFERKLQQLE 120
  121 KELKNEDENF ELDINSKKDK YALFSSSSDP SRRTNILSDR ARDLDLNEIF TRDEQYGEYM 180
  181 ELEQFHSLWL NVIKRGDCSL LQFLDILELF LDDEKYLLTP PMDRKNDRYM AFLLKLSKYV 240
  241 ETFFFKSYAL LDAAAVENLI KSDFEHSYCR GSLRSEAKGI YCPFCSRWFK TSSVFESHLV 300
  301 GKIHKKNESK RRNFVYSEYK LHRYLKYLND EFSRTRSFVE RKLAFTANER MAEMDILTQK 360
  361 YEAPAYDSTE KEGAEQVDGE QRDGQLQEEH LSGKSFDMPL GPDGLPMPYW LYKLHGLDRE 420
  421 YRCEICSNKV YNGRRTFERH FNEERHIYHL RCLGIEPSSV FKGITKIKEA QELWKNMQGQ 480
  481 SQLTSIAAVP PKPNPSQLKV PTELELEEED EEGNVMSKKV YDELKKQGLV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 CLF1 CSN12 CUS1 CWC2 CWC23 DIB1 ECM2 HSH155 LEA1 MSL1 PRP11 PRP19 PRP21 PRP3 PRP31 PRP39 PRP4 PRP46 PRP6 PRP8 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SNT309 SNU114 SNU23 SNU66 SNU71 SPP382 STO1 SYF1
    View Details (MIPS) Mewes HW, et al. (2004) PRP11 PRP9
    View Details Krogan NJ, et al. (2006) BUD13 BUD31 CUS1 CWC21 HSH155 HSH49 LEA1 LOT6 PRP11 PRP21 PRP45 PRP9 RSE1
    View Details Gavin AC, et al. (2006) BRR2 CUS1 HSH155 HSH49 LEA1 MSL1 PRP11 PRP21 PRP3 PRP31 PRP4 PRP6 PRP8 PRP9 RSE1 SMB1 SNU114 SNU23 SNU66 SPP381
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CBC2 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC21 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 HSH155 HSH49 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM6 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RDS3 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIA1 PRP9 2 Hazbun TR, et al. (2003)
    View Screen SPE1 PRP9 2 Unpublished Fields Lab Data
    View Screen SAS3 PRP9 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRP9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..212] MSA 1.012986 View MSA. No confident structure predictions are available.
    2 View Details [213..530] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.37529385176635 bayes_pls_golite062009
  • DNA binding
    		•  3.3049326844117 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.24981360535232 bayes_pls_golite062009
  • snRNA binding
    		•  3.16782731106334 bayes_pls_golite062009
  • RNA binding
    		•  3.11293528368816 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.86343975521155 bayes_pls_golite062009
  • transcription factor activity
    		•  2.44389510173662 bayes_pls_golite062009
  • binding
    		•  2.40458515823407 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.57041104288348 bayes_pls_golite062009
  • mRNA binding
    		•  1.28525296322454 bayes_pls_golite062009
  • transcription activator activity
    		•  1.20323819132961 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.732558534458316 bayes_pls_golite062009
  • protein binding
    		•  0.702841772031834 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.686318575498149 bayes_pls_golite062009
  • chromatin binding
    		•  0.626365497850853 bayes_pls_golite062009
  • transcription factor binding
    		•  0.515821187939278 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.200483461579207 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.113925660147477 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0855506955761403 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle