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Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. The aggregation, arrangement and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. Splicing of RNA via a series of two transesterification reactions. The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nuclear mRNA splicing, via spliceosome
Acc: GO:0000398
Aspect: Biological Process
Desc: The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
Synonyms:
  • nuclear mRNA splicing via U2-type spliceosome
  • mRNA splicing
  • nuclear mRNA splicing via U12-type spliceosome
  • splicing AT-AC intron
  • GO:0006374
  • splicing GT-AG intron
  • GO:0006375
  • pre-mRNA splicing
Proteins in PDR annotated with:
   This term: 631 [Search]
   Term or descendants: 844 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000398 - nuclear mRNA splicing, via spliceosome (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle