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Protein Overview: NTC20

General Information:
Name(s) found: NTC20 / YBR188C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 140 amino acids

    Gene Ontology:
    Cellular Component: spliceosomal complex [IDALink to PubMed article][IGILink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IDALink to PubMed article][IGILink to PubMed article]
    Molecular Function: first spliceosomal transesterification activity [IC]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSLRDLSLE RDQELNQLRA RINQLGKTGK EEANDFVGLN ISNEPVYDTV IQTGQSSNAT  60
   61 NSFVQETIQK TKQKESGQPY IIPQKNEHQR YIDKVCETSD LKAKLAPIME VLEKKTNEKI 120
  121 KGIIRKRVLQ EPDRDNDDSG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CWC21 NTC20 PRP3
    View Details Krogan NJ, et al. (2006) CEF1 CLF1 ISY1 NTC20 SEC6 SNT309 SYF1 SYF2
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 CBC2 CDC40 CEF1 CWC15 CWC2 CWC22 HSH155 ISY1 LSM2 LSM4 LSM5 LUC7 MUD1 MUD2 NTC20 PRP11 PRP16 PRP19 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP5 PRP8 PRP9 RPL41A, RPL41B RPS16B, RPS16A RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU56 SNU71 SPP381 SPP382 SUB2 SYF2 TOS4 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NTC20 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle