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Protein Overview: PRP4

General Information:
Name(s) found: PRP4 / YPR178W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Splicing factor, component of the U4/U6-U5 snRNP complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 465 amino acids

    Gene Ontology:
    Cellular Component: U4/U6 x U5 tri-snRNP complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKYIALENL PVDLQHKGAT QNESTADILK QLPHERLQAV LEKIPEEDLE VRRLLSILKK  60
   61 PEVVENEDVQ QRRIRLAEIL MVDEIDLENI NNMENINGEE VDEEDDEDFF TPATSELIFA 120
  121 RRFLINYSLE RSRKRLQKEM ERHQKFNTRQ ELLSRRTELQ RMANLELAGS QLVSTKPISA 180
  181 VSLSTDDMVV ATGSWAGDLQ VLNSQTLQPL TQKLDSHVGK IGAIDWHPDS NNQMISCAED 240
  241 GLIKNFQYSN EEGGLRLLGD LVGHERRISD VKYHPSGKFI GSASHDMTWR LWDASTHQEL 300
  301 LLQEGHDKGV FSLSFQCDGS LVCSGGMDSL SMLWDIRSGS KVMTLAGHSK PIYTVAWSPN 360
  361 GYQVATGGGD GIINVWDIRK RDEGQLNQIL AHRNIVTQVR FSKEDGGKKL VSCGYDNLIN 420
  421 VYSSDTWLKM GSLAGHTDKI ISLDISNNSH FLVSGGWDRS IKLWN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) AAR2 BRR1 BRR2 CSN12 CUS1 DHH1 DIB1 HSH155 KEM1 LEA1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LSM8 MSL1 MUD1 PAT1 PRP11 PRP19 PRP21 PRP24 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP6 PRP8 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SME1 SMX3 SNP1 SNU114 SNU23 SNU66 SNU71 SPP381 SPP382
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) BUD21 GLK1 NOP58 PRP4 RRP9
    View Details Gavin AC, et al. (2006) BRR2 CUS1 LEA1 PRP21 PRP3 PRP31 PRP4 PRP6 PRP8 PRP9 SMB1 SNU114 SNU23 SNU66 SPP381
    View Details Gavin AC, et al. (2002) AAR2 ASC1 BRR1 BRX1 BUD31 CBC2 CBF5 CDC33 CEF1 CIC1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DBP9 DCP2 DHH1 DIB1 DRS1 ECM2 ERB1 FUN12 GAR1 GCN2 HAS1 HRT1 HSH155 HSH49 HTA1 IMG1 KRE33 KRR1 KRS1 LEA1 LHP1 LIN1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MAK21 MDN1 MIS1 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM7 NAM8 NHP2 NIP1 NOC2 NOG1 NOG2 NOP1 NOP12 NOP2 NOP4 NOP56 NOP6 NOP7 NPL3 NUG1 PAT1 POL2 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 PUF6 RLP7 RRP12 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SQS1 SRB2 SRO9 STO1 SYF1 TIF4631 TIF4632 TOS4 URB1 UTP10 UTP20 UTP21 YEF3 YML6 YMR310C YTM1
    View Details Ho Y, et al. (2002) ARP2 PRP3 PRP4 PRP6 STI1
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC21 CWC22 CWC23 DIB1 ECM2 GTS1 HSH155 HSH49 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRP4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] PSI-BLAST 5.0 Surface layer protein
    2 View Details [127..465] PSI-BLAST 339.450636 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
    		• 6.67009948605948 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K4 specific)
    		•  4.71992275913384 bayes_pls_golite062009
  • GTPase activity
    		•  4.02994814377904 bayes_pls_golite062009
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.25521258308263 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • snoRNA binding
    		•  2.27164613239345 bayes_pls_golite062009
  • dynactin binding
    		•  2.07556426531897 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.85632145559025 bayes_pls_golite062009
  • structural molecule activity
    		•  1.47097979074281 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.35170368882651 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.25687092973217 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.22384651674093 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.20712373307552 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.11754260203517 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • type 1 angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • DNA binding
    		•  0.711274653406079 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.702111212042669 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • receptor binding
    		•  0.316169754698691 bayes_pls_golite062009
  • transcription factor activity
    		•  0.243992994917491 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  0.231534552000461 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.161639372576406 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.157016319695991 bayes_pls_golite062009
  • chromatin binding
    		•  0.145491963066342 bayes_pls_golite062009
  • myosin II binding
    		•  0.12060669039328 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.00335766408304172 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle