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Protein Overview: UTP21

General Information:
Name(s) found: UTP21 / YLR409C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 939 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear outer membrane [IPILink to PubMed article][RCALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: snoRNA binding [RCALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIDLKKRKV EEDVRSRGKN SKIFSPFRII GNVSNGVPFA TGTLGSTFYI VTCVGKTFQI  60
   61 YDANTLHLLF VSEKETPSSI VALSAHFHYV YAAYENKVGI YKRGIEEHLL ELETDANVEH 120
  121 LCIFGDYLCA STDDNSIFIY KKSDPQDKYP SEFYTKLTVT EIQGGEIVSL QHLATYLNKL 180
  181 TVVTKSNVLL FNVRTGKLVF TSNEFPDQIT TAEPAPVLDI IALGTVTGEV IMFNMRKGKR 240
  241 IRTIKIPQSR ISSLSFRTDG SSHLSVGTSS GDLIFYDLDR RSRIHVLKNI HRESYGGVTQ 300
  301 ATFLNGQPII VTSGGDNSLK EYVFDPSLSQ GSGDVVVQPP RYLRSRGGHS QPPSYIAFAD 360
  361 SQSHFMLSAS KDRSLWSFSL RKDAQSQEMS QRLHKKQDGG RVGGSTIKSK FPEIVALAIE 420
  421 NARIGEWENI ITAHKDEKFA RTWDMRNKRV GRWTFDTTDD GFVKSVAMSQ CGNFGFIGSS 480
  481 NGSITIYNMQ SGILRKKYKL HKRAVTGISL DGMNRKMVSC GLDGIVGFYD FNKSTLLGKL 540
  541 KLDAPITAMV YHRSSDLFAL ALDDLSIVVI DAVTQRVVRQ LWGHSNRITA FDFSPEGRWI 600
  601 VSASLDSTIR TWDLPTGGCI DGIIVDNVAT NVKFSPNGDL LATTHVTGNG ICIWTNRAQF 660
  661 KTVSTRTIDE SEFARMALPS TSVRGNDSML SGALESNGGE DLNDIDFNTY TSLEQIDKEL 720
  721 LTLSIGPRSK MNTLLHLDVI RKRSKPKEAP KKSEKLPFFL QLSGEKVGDE ASVREGIAHE 780
  781 TPEEIHRRDQ EAQKKLDAEE QMNKFKVTGR LGFESHFTKQ LREGSQSKDY SSLLATLINF 840
  841 SPAAVDLEIR SLNSFEPFDE IVWFIDALTQ GLKSNKNFEL YETFMSLLFK AHGDVIHANN 900
  901 KNQDIASALQ NWEDVHKKED RLDDLVKFCM GVAAFVTTA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 DIP2 ECM16 EMG1 ENP2 IMP3 KRE33 MPP10 NAN1 NOC4 NOP1 NOP56 PWP2 ROK1 RRP9 SOF1 UTP10 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8
    View Details Krogan NJ, et al. (2006) DIP2 HSV2 PWP2 UTP13 UTP18 UTP21 UTP6 YJL147C
    View Details Gavin AC, et al. (2006) CMS1 DIP2 MRD1 NAN1 NOP58 PNO1 PWP2 ROK1 RRP9 UTP10 UTP13 UTP15 UTP18 UTP21 UTP22 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Gavin AC, et al. (2002) AAR2 ADE4 ASC1 BFR2 BMS1 BRR1 BRX1 BUD21 BUD31 CBF5 CDC33 CEF1 CFT2 CIC1 CKA1 CKA2 CKB1 CKB2 CLF1 CMS1 CSN12 CUS1 CWC2 CWC22 CWC23 DBP8 DBP9 DHH1 DIA4 DIB1 DIM1 DIP2 DIS3 DRS1 ECM16 ECM2 ECM29 EMG1 ENP1 ENP2 ERB1 ERO1 ESF1 ESF2 FAP7 FIP1 FUN12 GAR1 GCN1 GCN2 GLC7 HAS1 HCA4 HHF1, HHF2 HSH155 HSL1 HTA1 HTA2 IMG1 IMP3 IMP4 KRE33 KRR1 LCP5 LEA1 LHP1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LTV1 LUC7 MAK21 MDN1 MIS1 MPP10 MRD1 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 MVD1 NAN1 NHP2 NIP1 NOB1 NOC2 NOC4 NOG1 NOP1 NOP12 NOP14 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NUG1 PAP1 PAT1 PFS2 PNO1 POL2 PRE6 PRE9 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 PTA1 PTI1 PUF6 PWP2 RCL1 REF2 RLP7 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RSE1 RTG2 RVB2 SAM1 SCL1 SEC21 SLU7 SLX9 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SOF1 SPP381 SPP382 SRB2 SRO9 STO1 SYF1 TIF1, TIF2 TIF4631 TIF4632 TOS4 TSR1 URB1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YML6 YMR310C YOR059C YSH1 YTM1
    View Details Ho Y, et al. (2002) AVT2 CKA1 CKA2 CKB1 CKB2 DIP2 ESL2 HOS4 KRE33 LCP5 NAN1 NOP1 NOP56 PNO1 PRP40 PTC5 PWP2 RRP5 SIF2 SNT1 TFP1 TRM3 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6 YMR155W YRF1-3, YRF1-7 ZDS2
    View Details Qiu et al. (2008) BUD21 DIP2 DRS1 ENP1 NAN1 NHP2 PWP2 RRP9 SOF1 UTP11 UTP15 UTP21 UTP22 UTP6 UTP7 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UTP21 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..315] PSI-BLAST 127.69897 beta1-subunit of the signal-transducing G protein heterotrimer
    2 View Details [316..657] PSI-BLAST 110.9794 Groucho/tle1, C-terminal domain
    3 View Details [658..746] PSI-BLAST 135.54902 Tup1, C-terminal domain
    4 View Details [747..939] MSA 1.118977 View MSA. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle