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Protein Overview: NOP4

General Information:
Name(s) found: NOP4 / YPL043W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 685 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [TASLink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [TASLink to PubMed article]
    Molecular Function: RNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEETIENVEV PSSNVSKQND DGLDMKTLFV RSIPQDVTDE QLADFFSNFA PIKHAVVVKD  60
   61 TNKRSRGFGF VSFAVEDDTK EALAKARKTK FNGHILRVDI AKRRDRSKKT SEVVEKSTPE 120
  121 SSEKITGQNN EDEDDADGED SMLKGKPKLI IRNMPWSCRD PVKLKKIFGR YGTVVEATIP 180
  181 RKRDGKLCGF AFVTMKKISN CRIALENTKD LKIDGRKVAV DFAVQKNRWE DYKKAQPEMN 240
  241 DKDDNESGNE DAEENHDDEE DENEEEDRQV DQASKNKESK RKAQNKREDF SVFVRNVPYD 300
  301 ATEESLAPHF SKFGSVKYAL PVIDKSTGLA KGTAFVAFKD QYTYNECIKN APAAGSTSLL 360
  361 IGDDVMPEYV YEGRVLSITP TLVREDAGRM AEKNAAKRKE ALGKAPGEKD RRNLYLLNEG 420
  421 RVVEGSKMAD LLTNTDMEIR EKSYKLRVEQ LKKNPSLHLS MTRLAIRNLP RAMNDKALKA 480
  481 LARKAVVEFA TEVKNKERHP LSKEEIIRST KEKYKFMGPD EIEAQKKKDK KSGVVKQAKV 540
  541 IMEVKGSTAG RSRGYGFVEF RDHKNALMGL RWLNCHAVTS DEILEGLNDD EKKQVDNDLG 600
  601 KGRRLCVEFA IENSNVVKRR REQLKQARTK RTRPDNEDTG DVGESENKKP KKEEATTPTN 660
  661 PDDKKMGDDI KRIIGFKRKR KHAKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CIC1 DBP10 DBP9 DRS1 ERB1 HAS1 MAK21 MAK5 NIP7 NOC2 NOG1 NOP12 NOP15 NOP2 NOP4 NOP7 NSA1 NUG1 PUF6 RIX7 RLP7 RPF1 RRP12 TIF4632 TIF6 URB1 UTP20 YTM1
    View Details Gavin AC, et al. (2006) BRX1 CIC1 DBP10 DBP9 ERB1 MAK21 MAK5 NOC2 NOP13 NOP4 PUF6 RLP7 RSA3 SPB4 YTM1
    View Details Gavin AC, et al. (2002) AAR2 ARX1 BEM2 BMS1 BRX1 BUD20 CBF5 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 FUN12 GAR1 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 KRR1 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRP7 MRT4 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP6 NOP7 NSA1 NSA2 NUG1 POL2 PRP4 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMB1 SNU114 SNU13 SNU66 SPB1 SPB4 SRO9 SSF1 TIF4631 TIF4632 TIF6 TUB3 URB1 UTP10 UTP20 UTP21 UTP22 YGL036W YMR310C YTM1
    View Details Ho Y, et al. (2002) AIM46 APL2 APL4 APM1 ARC18 ARC35 ARC40 ARE1 ARP2 ARP3 BRX1 CDC33 CIC1 CKA1 CKB1 CKB2 DBP2 EBP2 EGD1 ENP2 ERB1 FET4 FPR3 FUN12 GRS1 HAS1 HHF1, HHF2 HHT1, HHT2 HIR2 HOT1 HTA1 HTB1 HTB2 IMD2 IMD3 IMD4 KAP114 KRE33 KRI1 KRR1 MAG2 MGM101 MSC3 MSS116 NAP1 NIP1 NMA1 NOC2 NOG1 NOP12 NOP13 NOP2 NOP4 NOP56 NOP7 NPL3 NUG1 OSH3 OYE2 PAB1 PDC6 PDI1 POB3 PUF6 PWP1 RCL1 RET1 RPC82 RPF2 RPO31 RRP12 SPT16 SSF1 SSZ1 TIF4631 TIF4632 TIF6 TUF1 UTP13 UTP22 YER084W YLR241W YNL040W
    View Details Qiu et al. (2008) BRX1 DBP3 DBP6 DBP7 DHR2 DRS1 ERB1 GAR1 HAS1 IFH1 MAK5 MRT4 NAN1 NOP13 NOP15 NOP4 NSR1 NUG1 RNT1 RPF2 SOF1 SPB4 UTP13 UTP15 UTP4 UTP5 UTP6 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NOP4 Huh WK, et al. (2003)
    View Data NOP4 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 93.264245 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    2 View Details [124..255] PSI-BLAST 93.264245 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    3 View Details [256..383] PSI-BLAST 76.927757 Poly(A)-binding protein
    4 View Details [384..500] PSI-BLAST 76.927757 Poly(A)-binding protein
    5 View Details [501..633] PSI-BLAST 93.232149 Crystal Structure of UP1 Complexed With d(TAGG(6MI)TTAGGG): A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6MI)
    6 View Details [634..685] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle