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Protein Overview: OSH3

General Information:
Name(s) found: OSH3 / YHR073W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 996 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: sterol transport [IGILink to PubMed article][IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed articleLink to PubMed article]
    invasive growth in response to glucose limitation [IGILink to PubMed article]
    karyogamy involved in conjugation with cellular fusion [IGILink to PubMed article]
    endocytosis [IGILink to PubMed article]
    exocytosis [IGILink to PubMed article]
    Molecular Function: oxysterol binding [ISSLink to PubMed article]
    phosphatidylinositol binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METIDIQNRS FVVRWVKCGR GDVINYQIKP LKKSIEVGIY KKLKSSVDDH ASAVHIAPDT  60
   61 KTLLDYTTKS LLHKGSSSNI EEHHRRSSQH SHSSSNGSDN KRKERSYSSL SISGIQQQSQ 120
  121 EIPLREKLSA SGFTLVKRVG NVSGNTMVQG DLEVKDTDYY YAFILDNSSS KNAKKKILFN 180
  181 ASVINGDNQS MISTRSTPPA RPTALSRTST QQDMLFRVGQ GRYLQGYLLK KRRKRLQGFK 240
  241 KRFFTLDFRY GTLSYYLNDH NQTCRGEIVI SLSSVSANKK DKIIIIDSGM EVWVLKATTK 300
  301 ENWQSWVDAL QTCFDDQFED KDTSTLEENP DILDDDKEVI NKSSPQDHDH LTPTATTKSA 360
  361 LSHRQHTQKD MDDIYVPLPS ESYATFSMNL RLIQQRLEQC KKDSLSYKPT TLHQRSEGLN 420
  421 GTHSSSSVFT NNRVSSFNHS SSGMTSSDSL ASEEVPSNKT YIEHALYNQL ADLEVFVSRF 480
  481 VTQGEVLFKD HQILCKKAKD TRVSLTSYLS ENDEFFDAEE EISRGVIILP DTEDDINNIV 540
  541 EETPLLGKSD QNEFTKEVQL SGSEQIASSS VESYTTNDEN HSRKHLKNRH KNRRRGHPHH 600
  601 QKTKSAQSST ETFTSKDLFA LSYPKSVTRR NDIPEAAASP PSLLSFLRKN VGKDLSSIAM 660
  661 PVTSNEPISI LQLISETFEY APLLTKATQR PDPITFVSAF AISFLSIYRD KTRTLRKPFN 720
  721 PLLAETFELI REDMGFRLIS EKVSHRPPVF AFFAEHLDWE CSYTVTPSQK FWGKSIELNN 780
  781 EGILRLKFKT TGELFEWTQP TTILKNLIAG ERYMEPVNEF EVHSSKGDKS HILFDKAGMF 840
  841 SGRSEGFKVS IIPPPSSNRK KETLAGKWTQ SLANETTHET IWEVGDLVSN PKKKYGFTKF 900
  901 TANLNEITEI EKGNLPPTDS RLRPDIRAYE EGNVDKAEEW KLKLEQLQRE RRNKGQDVEP 960
  961 KYFEKVSKNE WKYITGPKSY WERRKKHDWS DISQLW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) COR1 OSH3 QCR2
    View Details Ho Y, et al. (2002) NOP4 OSH3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OSH3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..109] PSI-BLAST 23.69897 Pleckstrin, N-terminal domain
    2 View Details [110..199] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [200..341] PSI-BLAST 16.522879 Insulin receptor substrate 1, IRS-1
    4 View Details [342..470] PSI-BLAST 16.522879 Insulin receptor substrate 1, IRS-1
    5 View Details [471..603] deduced N/A No confident structure predictions are available.
    6 View Details [604..996] MSA 13.089929 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.66299247672855 bayes_pls_golite062009
  • protein binding
    		•  2.02185635612105 bayes_pls_golite062009
  • phospholipid binding
    		•  0.55366417165491 bayes_pls_golite062009
  • oxysterol binding
    		•  0.388611951740269 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.378341925097039 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.3294481483029 bayes_pls_golite062009
  • actin binding
    		•  0.19177000642445 bayes_pls_golite062009
  • receptor binding
    		•  0.15607515882138 bayes_pls_golite062009
  • transporter activity
    		•  0.0356867444078989 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.66299247672855 bayes_pls_golite062009
  • protein binding
    		•  2.02185635612105 bayes_pls_golite062009
  • phospholipid binding
    		•  0.55366417165491 bayes_pls_golite062009
  • oxysterol binding
    		•  0.388611951740269 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.378341925097039 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.3294481483029 bayes_pls_golite062009
  • actin binding
    		•  0.19177000642445 bayes_pls_golite062009
  • receptor binding
    		•  0.15607515882138 bayes_pls_golite062009
  • transporter activity
    		•  0.0356867444078989 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • oxysterol binding
    		•  5.22335714957681 bayes_pls_golite062009
  • sterol binding
    		•  4.18891468109664 bayes_pls_golite062009
    		• 3.02967613614595 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • binding
    		•  1.90982981425351 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.88386267925687 bayes_pls_golite062009
  • phospholipid binding
    		•  1.53854106315366 bayes_pls_golite062009
  • lipid binding
    		•  1.52883493550389 bayes_pls_golite062009
  • cholesterol binding
    		•  0.644339278395346 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle