YRC Public Data Repository - Protein Structure Prediction

Protein:	OSH3
Organism:	Saccharomyces cerevisiae
Length:	996 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OSH3.

Description	E-value	Query Range	Subject Range
OSH3_YEAST - Oxysterol-binding protein homolog 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OSH3... gi\|151944018 - gi\|151944018\|gb\|EDN62311.1\| oxysterol-binding family protein [Saccharomyces cerevisiae YJM789] OSH3 - Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members ha...	0.0	[1..996]	[1..996]
OSBPL6 - oxysterol binding protein-like 6	0.0	[136..993]	[1..929]
gi\|16117300 - gi\|16117300\|dbj\|BAB03559.2\| hypothetical protein [Macaca fascicularis]	0.0	[228..993]	[1..826]
ORP3_MOUSE, OSBL... - Oxysterol-binding protein-related protein 3 OS=Mus musculus GN=Osbpl3 PE=1 SV=1, (Q9DBS9) Oxysterol ...	0.0	[185..994]	[2..851]

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Predicted Domain #1

Region A:
Residues: [1-109]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METIDIQNRS FVVRWVKCGR GDVINYQIKP LKKSIEVGIY KKLKSSVDDH ASAVHIAPDT  60
   61 KTLLDYTTKS LLHKGSSSNI EEHHRRSSQH SHSSSNGSDN KRKERSYSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.69897
Match:	1pls__
Description:	Pleckstrin, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.66299247672855	bayes_pls_golite062009
protein binding	2.02185635612105	bayes_pls_golite062009
phospholipid binding	0.55366417165491	bayes_pls_golite062009
oxysterol binding	0.388611951740269	bayes_pls_golite062009
cytoskeletal protein binding	0.378341925097039	bayes_pls_golite062009
phosphoinositide binding	0.3294481483029	bayes_pls_golite062009
actin binding	0.19177000642445	bayes_pls_golite062009
receptor binding	0.15607515882138	bayes_pls_golite062009
transporter activity	0.0356867444078989	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [110-199]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSISGIQQQS QEIPLREKLS ASGFTLVKRV GNVSGNTMVQ GDLEVKDTDY YYAFILDNSS  60
   61 SKNAKKKILF NASVINGDNQ SMISTRSTPP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.749	0.864	steroid biosynthetic process	b.1.2	Fibronectin type III

Predicted Domain #3

Region A:
Residues: [200-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARPTALSRTS TQQDMLFRVG QGRYLQGYLL KKRRKRLQGF KKRFFTLDFR YGTLSYYLND  60
   61 HNQTCRGEIV ISLSSVSANK KDKIIIIDSG MEVWVLKATT KENWQSWVDA LQTCFDDQFE 120
  121 DKDTSTLEEN PDILDDDKEV IN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.522879
Match:	1qqgA_
Description:	Insulin receptor substrate 1, IRS-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.66299247672855	bayes_pls_golite062009
protein binding	2.02185635612105	bayes_pls_golite062009
phospholipid binding	0.55366417165491	bayes_pls_golite062009
oxysterol binding	0.388611951740269	bayes_pls_golite062009
cytoskeletal protein binding	0.378341925097039	bayes_pls_golite062009
phosphoinositide binding	0.3294481483029	bayes_pls_golite062009
actin binding	0.19177000642445	bayes_pls_golite062009
receptor binding	0.15607515882138	bayes_pls_golite062009
transporter activity	0.0356867444078989	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [342-470]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSSPQDHDHL TPTATTKSAL SHRQHTQKDM DDIYVPLPSE SYATFSMNLR LIQQRLEQCK  60
   61 KDSLSYKPTT LHQRSEGLNG THSSSSVFTN NRVSSFNHSS SGMTSSDSLA SEEVPSNKTY 120
  121 IEHALYNQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.522879
Match:	1qqgA_
Description:	Insulin receptor substrate 1, IRS-1
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [471-603]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADLEVFVSRF VTQGEVLFKD HQILCKKAKD TRVSLTSYLS ENDEFFDAEE EISRGVIILP  60
   61 DTEDDINNIV EETPLLGKSD QNEFTKEVQL SGSEQIASSS VESYTTNDEN HSRKHLKNRH 120
  121 KNRRRGHPHH QKT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
oxysterol binding	5.22335714957681	bayes_pls_golite062009
sterol binding	4.18891468109664	bayes_pls_golite062009
	3.02967613614595	bayes_pls_golite062009
steroid binding	2.54679035876403	bayes_pls_golite062009
binding	1.90982981425351	bayes_pls_golite062009
phosphoinositide binding	1.88386267925687	bayes_pls_golite062009
phospholipid binding	1.53854106315366	bayes_pls_golite062009
lipid binding	1.52883493550389	bayes_pls_golite062009
cholesterol binding	0.644339278395346	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [604-996]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSAQSSTETF TSKDLFALSY PKSVTRRNDI PEAAASPPSL LSFLRKNVGK DLSSIAMPVT  60
   61 SNEPISILQL ISETFEYAPL LTKATQRPDP ITFVSAFAIS FLSIYRDKTR TLRKPFNPLL 120
  121 AETFELIRED MGFRLISEKV SHRPPVFAFF AEHLDWECSY TVTPSQKFWG KSIELNNEGI 180
  181 LRLKFKTTGE LFEWTQPTTI LKNLIAGERY MEPVNEFEVH SSKGDKSHIL FDKAGMFSGR 240
  241 SEGFKVSIIP PPSSNRKKET LAGKWTQSLA NETTHETIWE VGDLVSNPKK KYGFTKFTAN 300
  301 LNEITEIEKG NLPPTDSRLR PDIRAYEEGN VDKAEEWKLK LEQLQRERRN KGQDVEPKYF 360
  361 EKVSKNEWKY ITGPKSYWER RKKHDWSDIS QLW

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: