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View Structure Prediction Details

Protein: OSH3
Organism: Saccharomyces cerevisiae
Length: 996 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OSH3.

Description E-value Query
Range		 Subject
Range
OSH3_YEAST - Oxysterol-binding protein homolog 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OSH3...
gi|151944018 - gi|151944018|gb|EDN62311.1| oxysterol-binding family protein [Saccharomyces cerevisiae YJM789]
OSH3 - Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members ha...
 0.0 [1..996] [1..996]
OSBPL6 - oxysterol binding protein-like 6
 0.0 [136..993] [1..929]
gi|16117300 - gi|16117300|dbj|BAB03559.2| hypothetical protein [Macaca fascicularis]
 0.0 [228..993] [1..826]
ORP3_MOUSE, OSBL... - Oxysterol-binding protein-related protein 3 OS=Mus musculus GN=Osbpl3 PE=1 SV=1, (Q9DBS9) Oxysterol ...
 0.0 [185..994] [2..851]

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Predicted Domain #1
Region A:
Residues: [1-109] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METIDIQNRS FVVRWVKCGR GDVINYQIKP LKKSIEVGIY KKLKSSVDDH ASAVHIAPDT  60
   61 KTLLDYTTKS LLHKGSSSNI EEHHRRSSQH SHSSSNGSDN KRKERSYSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.69897
Match: 1pls__
Description: Pleckstrin, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.66299247672855 bayes_pls_golite062009
protein binding 2.02185635612105 bayes_pls_golite062009
phospholipid binding 0.55366417165491 bayes_pls_golite062009
oxysterol binding 0.388611951740269 bayes_pls_golite062009
cytoskeletal protein binding 0.378341925097039 bayes_pls_golite062009
phosphoinositide binding 0.3294481483029 bayes_pls_golite062009
actin binding 0.19177000642445 bayes_pls_golite062009
receptor binding 0.15607515882138 bayes_pls_golite062009
transporter activity 0.0356867444078989 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [110-199] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSISGIQQQS QEIPLREKLS ASGFTLVKRV GNVSGNTMVQ GDLEVKDTDY YYAFILDNSS  60
   61 SKNAKKKILF NASVINGDNQ SMISTRSTPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.749 0.864 steroid biosynthetic process b.1.2 Fibronectin type III
View Download 0.688 0.864 steroid biosynthetic process b.1.1 Immunoglobulin
View Download 0.672 0.864 steroid biosynthetic process b.1.18 E set domains
View Download 0.744 0.864 steroid biosynthetic process d.233.1 Inhibitor of vertebrate lysozyme, Ivy
View Download 0.717 0.864 steroid biosynthetic process b.1.2 Fibronectin type III
View Download 0.665 0.864 steroid biosynthetic process d.17.1 Cystatin/monellin
View Download 0.618 0.864 steroid biosynthetic process d.50.1 dsRNA-binding domain-like
View Download 0.615 0.864 steroid biosynthetic process d.93.1 SH2 domain
View Download 0.595 0.864 steroid biosynthetic process b.4.1 HSP40/DnaJ peptide-binding domain
View Download 0.581 0.864 steroid biosynthetic process d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.579 0.864 steroid biosynthetic process d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.565 0.864 steroid biosynthetic process b.1.2 Fibronectin type III
View Download 0.551 0.864 steroid biosynthetic process d.93.1 SH2 domain
View Download 0.542 0.864 steroid biosynthetic process b.105.1 Penicillin-binding protein 5, C-terminal domain
View Download 0.536 0.864 steroid biosynthetic process d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.535 0.864 steroid biosynthetic process b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.535 0.864 steroid biosynthetic process d.93.1 SH2 domain
View Download 0.483 0.864 steroid biosynthetic process b.40.2 Bacterial enterotoxins
View Download 0.481 0.864 steroid biosynthetic process d.58.2 Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
View Download 0.480 0.864 steroid biosynthetic process b.1.1 Immunoglobulin
View Download 0.479 0.864 steroid biosynthetic process b.3.1 Starch-binding domain
View Download 0.478 0.864 steroid biosynthetic process d.1.1 Microbial ribonucleases
View Download 0.476 0.864 steroid biosynthetic process b.1.12 Purple acid phosphatase, N-terminal domain
View Download 0.465 0.864 steroid biosynthetic process b.1.18 E set domains
View Download 0.462 0.864 steroid biosynthetic process c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.460 0.864 steroid biosynthetic process d.93.1 SH2 domain
View Download 0.455 0.864 steroid biosynthetic process d.15.9 Glutamine synthetase, N-terminal domain
View Download 0.447 0.864 steroid biosynthetic process b.1.18 E set domains
View Download 0.439 0.864 steroid biosynthetic process d.95.2 Homing endonucleases
View Download 0.429 0.864 steroid biosynthetic process b.1.2 Fibronectin type III
View Download 0.422 0.864 steroid biosynthetic process b.3.4 Transthyretin (prealbumin)
View Download 0.421 0.864 steroid biosynthetic process b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.420 0.864 steroid biosynthetic process b.1.1 Immunoglobulin
View Download 0.416 0.864 steroid biosynthetic process d.17.1 Cystatin/monellin
View Download 0.410 0.864 steroid biosynthetic process d.82.2 Frataxin-like
View Download 0.409 0.864 steroid biosynthetic process d.85.1 RNA bacteriophage capsid protein
View Download 0.391 0.864 steroid biosynthetic process b.60.1 Lipocalins
View Download 0.387 0.864 steroid biosynthetic process d.17.4 NTF2-like
View Download 0.384 0.864 steroid biosynthetic process b.60.1 Lipocalins
View Download 0.382 0.864 steroid biosynthetic process d.129.3 Bet v1-like
View Download 0.380 0.864 steroid biosynthetic process b.1.2 Fibronectin type III
View Download 0.370 0.864 steroid biosynthetic process d.17.4 NTF2-like
View Download 0.370 0.864 steroid biosynthetic process b.3.5 B repeat unit of collagen binding surface protein (cna)
View Download 0.365 0.864 steroid biosynthetic process b.40.2 Bacterial enterotoxins
View Download 0.362 0.864 steroid biosynthetic process d.110.3 PYP-like sensor domain (PAS domain)
View Download 0.346 0.864 steroid biosynthetic process b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.345 0.864 steroid biosynthetic process d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.344 0.864 steroid biosynthetic process d.204.1 Ribosome binding protein Y (YfiA homologue)
View Download 0.343 0.864 steroid biosynthetic process b.34.5 Translation proteins SH3-like domain
View Download 0.342 0.864 steroid biosynthetic process b.1.2 Fibronectin type III
View Download 0.339 0.864 steroid biosynthetic process d.233.1 Inhibitor of vertebrate lysozyme, Ivy
View Download 0.337 0.864 steroid biosynthetic process b.55.1 PH domain-like
View Download 0.326 0.864 steroid biosynthetic process d.93.1 SH2 domain
View Download 0.323 0.864 steroid biosynthetic process b.4.1 HSP40/DnaJ peptide-binding domain
View Download 0.321 0.864 steroid biosynthetic process b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.321 0.864 steroid biosynthetic process b.1.18 E set domains
View Download 0.318 0.864 steroid biosynthetic process b.26.1 SMAD/FHA domain
View Download 0.317 0.864 steroid biosynthetic process d.24.1 Pili subunits
View Download 0.316 0.864 steroid biosynthetic process d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.310 0.864 steroid biosynthetic process d.50.1 dsRNA-binding domain-like
View Download 0.304 0.864 steroid biosynthetic process b.1.1 Immunoglobulin
View Download 0.300 0.864 steroid biosynthetic process c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.298 0.864 steroid biosynthetic process g.18.1 Complement control module/SCR domain
View Download 0.294 0.864 steroid biosynthetic process b.1.6 Cadherin
View Download 0.292 0.864 steroid biosynthetic process d.106.1 Sterol carrier protein, SCP
View Download 0.289 0.864 steroid biosynthetic process b.122.1 PUA domain-like
View Download 0.283 0.864 steroid biosynthetic process d.110.1 Profilin (actin-binding protein)
View Download 0.282 0.864 steroid biosynthetic process d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.275 0.864 steroid biosynthetic process b.61.1 Avidin/streptavidin
View Download 0.268 0.864 steroid biosynthetic process d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.241 0.864 steroid biosynthetic process b.38.1 Sm-like ribonucleoproteins
View Download 0.231 0.864 steroid biosynthetic process b.1.6 Cadherin
View Download 0.228 0.864 steroid biosynthetic process b.61.1 Avidin/streptavidin
View Download 0.225 0.864 steroid biosynthetic process d.50.1 dsRNA-binding domain-like
View Download 0.221 0.864 steroid biosynthetic process b.55.1 PH domain-like
View Download 0.218 0.864 steroid biosynthetic process d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.211 0.864 steroid biosynthetic process d.58.26 GHMP Kinase, C-terminal domain
View Download 0.210 0.864 steroid biosynthetic process b.61.5 Dipeptidyl peptidase I (cathepsin C), exclusion domain
View Download 0.203 0.864 steroid biosynthetic process d.24.1 Pili subunits

Predicted Domain #3
Region A:
Residues: [200-341] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARPTALSRTS TQQDMLFRVG QGRYLQGYLL KKRRKRLQGF KKRFFTLDFR YGTLSYYLND  60
   61 HNQTCRGEIV ISLSSVSANK KDKIIIIDSG MEVWVLKATT KENWQSWVDA LQTCFDDQFE 120
  121 DKDTSTLEEN PDILDDDKEV IN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1qqgA_
Description: Insulin receptor substrate 1, IRS-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.66299247672855 bayes_pls_golite062009
protein binding 2.02185635612105 bayes_pls_golite062009
phospholipid binding 0.55366417165491 bayes_pls_golite062009
oxysterol binding 0.388611951740269 bayes_pls_golite062009
cytoskeletal protein binding 0.378341925097039 bayes_pls_golite062009
phosphoinositide binding 0.3294481483029 bayes_pls_golite062009
actin binding 0.19177000642445 bayes_pls_golite062009
receptor binding 0.15607515882138 bayes_pls_golite062009
transporter activity 0.0356867444078989 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [342-470] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSSPQDHDHL TPTATTKSAL SHRQHTQKDM DDIYVPLPSE SYATFSMNLR LIQQRLEQCK  60
   61 KDSLSYKPTT LHQRSEGLNG THSSSSVFTN NRVSSFNHSS SGMTSSDSLA SEEVPSNKTY 120
  121 IEHALYNQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1qqgA_
Description: Insulin receptor substrate 1, IRS-1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [471-603] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADLEVFVSRF VTQGEVLFKD HQILCKKAKD TRVSLTSYLS ENDEFFDAEE EISRGVIILP  60
   61 DTEDDINNIV EETPLLGKSD QNEFTKEVQL SGSEQIASSS VESYTTNDEN HSRKHLKNRH 120
  121 KNRRRGHPHH QKT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.209 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.250 a.25.1 Ferritin-like
View Download 0.230 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.201 a.118.1 ARM repeat
View Download 0.317 a.74.1 Cyclin-like

Predicted functions:

Term Confidence Notes
oxysterol binding 5.22335714957681 bayes_pls_golite062009
sterol binding 4.18891468109664 bayes_pls_golite062009
3.02967613614595 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
binding 1.90982981425351 bayes_pls_golite062009
phosphoinositide binding 1.88386267925687 bayes_pls_golite062009
phospholipid binding 1.53854106315366 bayes_pls_golite062009
lipid binding 1.52883493550389 bayes_pls_golite062009
cholesterol binding 0.644339278395346 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [604-996] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSAQSSTETF TSKDLFALSY PKSVTRRNDI PEAAASPPSL LSFLRKNVGK DLSSIAMPVT  60
   61 SNEPISILQL ISETFEYAPL LTKATQRPDP ITFVSAFAIS FLSIYRDKTR TLRKPFNPLL 120
  121 AETFELIRED MGFRLISEKV SHRPPVFAFF AEHLDWECSY TVTPSQKFWG KSIELNNEGI 180
  181 LRLKFKTTGE LFEWTQPTTI LKNLIAGERY MEPVNEFEVH SSKGDKSHIL FDKAGMFSGR 240
  241 SEGFKVSIIP PPSSNRKKET LAGKWTQSLA NETTHETIWE VGDLVSNPKK KYGFTKFTAN 300
  301 LNEITEIEKG NLPPTDSRLR PDIRAYEEGN VDKAEEWKLK LEQLQRERRN KGQDVEPKYF 360
  361 EKVSKNEWKY ITGPKSYWER RKKHDWSDIS QLW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle