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Protein Overview: NOG2

General Information:
Name(s) found: NOG2 / YNR053C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 486 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    nucleoplasm [IDALink to PubMed article]
    Biological Process: ribosomal large subunit export from nucleus [IMPLink to PubMed article][IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    ribosome assembly [TASLink to PubMed article]
    Molecular Function: GTPase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTGKKEKSR RIREGDTKDG NLRVKGENFY RDSKRVKFLN MYTSGKEIRN KKGNLIRAAS  60
   61 FQDSTIPDAR VQPDRRWFGN TRVISQDALQ HFRSALGETQ KDTYQVLLRR NKLPMSLLEE 120
  121 KDADESPKAR ILDTESYADA FGPKAQRKRP RLAASNLEDL VKATNEDITK YEEKQVLDAT 180
  181 LGLMGNQEDK ENGWTSAAKE AIFSKGQSKR IWNELYKVID SSDVVIHVLD ARDPLGTRCK 240
  241 SVEEYMKKET PHKHLIYVLN KCDLVPTWVA AAWVKHLSKE RPTLAFHASI TNSFGKGSLI 300
  301 QLLRQFSQLH TDRKQISVGF IGYPNTGKSS IINTLRKKKV CQVAPIPGET KVWQYITLMK 360
  361 RIFLIDCPGI VPPSSKDSEE DILFRGVVRV EHVTHPEQYI PGVLKRCQVK HLERTYEISG 420
  421 WKDATEFIEI LARKQGRLLK GGEPDESGVS KQILNDFNRG KIPWFVLPPE KEGEEKPKKK 480
  481 EVEKTA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARX1 BUD20 CIC1 DBP10 ERB1 HAS1 IPI1 IPI3 LSG1 MDN1 MRT4 NIP7 NOC3 NOG1 NOG2 NOP15 NOP7 NSA2 NUG1 PUF6 RIX1 RLP7 RPF2 RPL25 RPL27A RPL36B RPL38 RSA4 SDA1 TIF6
    View Details Krogan NJ, et al. (2006) NOG1 NOG2 NOP15 NUG1 YSW1
    View Details Gavin AC, et al. (2006) ARX1 BUD20 FPR4 IPI3 MRT4 NIP7 NOG1 NOG2 NOP2 NSA2 NUG1 RIX1 RPF2 RSA4 SDA1 TIF6
    View Details Gavin AC, et al. (2002) ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 ARX1 ASC1 BEM2 BMS1 BRX1 BUD20 CCT5 CCT8 CDC33 CIC1 CLF1 CLU1 CWC23 CYR1 CYS4 DBP10 DBP9 DCP2 DHH1 DIB1 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 KRS1 LHP1 LOC1 LSG1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAK21 MAK5 MDN1 MIS1 MRT4 NAM7 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PAT1 PFK1 PRP24 PRP31 PRP38 PRP4 PRP43 PRP46 PRP6 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMB1 SMD2 SNU114 SNU13 SNU23 SNU66 SPB1 SPB4 SPP382 SQS1 SRO9 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) ATP3 AVO1 CCT5 CLU1 DHH1 DPB2 FUN12 GAL7 GPH1 IDH1 ILV2 MET16 MKK2 NOG2 NPA3 PDX1 PHO85 PUF3 RPN12 SIS1 SLX1 SRP54 STI1 TEM1 TFC7 VMA8 YER077C YGR266W YKR051W YKU80 YLR271W YPR003C
    View Details Qiu et al. (2008) AIR1 DBP3 DRS1 MAK5 NOG2 NUG1 RIX7 RNT1 ROK1 SPB4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NOG2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] MSA 1.205968 View MSA. No confident structure predictions are available.
    2 View Details [113..312] PSI-BLAST 4.522879 cH-p21 Ras protein
    3 View Details [313..486] PSI-BLAST 31.0 GTPase Era, N-terminal domain; GTPase Era C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle