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Protein Overview: SLX1

General Information:
Name(s) found: SLX1 / YBR228W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 304 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: DNA-dependent DNA replication [IGILink to PubMed article]
    response to DNA damage stimulus [IGILink to PubMed article]
    Molecular Function: 5'-flap endonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQKIQQHQF PDFYCCYLLQ SINKRQSFYV GSTPNPVRRL RQHNGKLAVG GAYRTKRDGS  60
   61 RPWEMIMIVR GFPSKIAALQ FEHAWQHGYQ THYIAEKDRV VKHKAGGRTL HHKVALMKLL 120
  121 LKHEFFQRMN LIVEVFNIKA WEVWKQDKFF IERDRFPINI QINENALEEP KEKTVDVLMD 180
  181 HSDENLKVVE AVYTKVIENE RNIFETFEKK LTTGVVRCEI CEKEIDYTSE EQNLKPFVAL 240
  241 CNNKDCGCVN HLKCLHRYFL DDEQLMVGRR NLIPRGGKCP KCDMFCDWTT LVKFSTRMKL 300
  301 AHGK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE16 ADE17 SLX1
    View Details Ho Y, et al. (2002) ATP3 AVO1 CCT5 CLU1 DHH1 DPB2 FUN12 GAL7 GPH1 IDH1 ILV2 MET16 MKK2 NOG2 NPA3 PDX1 PHO85 PUF3 RPN12 SIS1 SLX1 SRP54 STI1 TEM1 TFC7 VMA8 YER077C YGR266W YKR051W YKU80 YLR271W YPR003C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] MSA 2.00998 View MSA. No confident structure predictions are available.
    2 View Details [168..304] deduced N/A No confident structure predictions are available.
    3 View Details [180..304] FFAS03 2.29 Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.56124977034668 bayes_pls_golite062009
  • protein binding
    		•  1.69332800381364 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.34809367817517 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.29443396975472 bayes_pls_golite062009
  • DNA binding
    		•  0.857401028646596 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.842690858803658 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.740437317894105 bayes_pls_golite062009
  • transcription factor binding
    		•  0.315997284960041 bayes_pls_golite062009
  • ligase activity
    		•  0.204285145398262 bayes_pls_golite062009
  • catalytic activity
    		•  0.168711389690753 bayes_pls_golite062009
  • transcription factor activity
    		•  0.14897188736485 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.121420290407334 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle