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Protein Overview: ADE17

General Information:
Name(s) found: ADE17 / YMR120C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 592 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: purine nucleotide biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article]
    'de novo' IMP biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: IMP cyclohydrolase activity [IDALink to PubMed article]
    phosphoribosylaminoimidazolecarboxamide formyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANYTKTAIL SVYDKTGLLD LARGLIEKNV RILASGGTAR MIRDAGFPIE DVSAITHAPE  60
   61 MLGGRVKTLH PAVHGGILAR DIDSDEKDLK EQHIEKVDYV VCNLYPFKET VAKVGVTIPE 120
  121 AVEEIDIGGV TLLRAAAKNH ARVTILSDPK DYSEFLSELS SNGEISQDLR NRLALKAFEH 180
  181 TADYDAAISD FFRKQYSEGQ AQITLRYGAN PHQKPAQAYV SQQDSLPFKV LCGSPGYINL 240
  241 LDALNSWPLV KELSASLNLP AAASFKHVSP AGAAVGIPLS DVEKQVYFVA DIENLSPLAC 300
  301 AYARARGADR MSSFGDWIAL SNIVDVPTAK IISREVSDGV IAPGYEPEAL AILSKKKGGK 360
  361 YCILQIDPNY VPEAVERRQV YGVTLEQKRN DAIINQSTFK EIVSQNKNLT EQAIIDLTVA 420
  421 TIAIKYTQSN SVCYARNGMV VGLGAGQQSR IHCTRLAGDK ADNWWFRQHP RVLEIKWAKG 480
  481 VKRPEKSNAI DLFVTGQIPT EEPELSEYQS KFEEIPKPFT PEERKEWLSK LTNVSLSSDA 540
  541 FFPFPDNVYR AVKSGVKYIA APSGSVMDKV VFSAADSFDL VYVENPIRLF HH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADE16 ADE17
    View Details Krogan NJ, et al. (2006) ADE16 ADE17 SLX1
    View Details Ho Y, et al. (2002) ADE17 MDH1 PGM2 PRP6 SEC53 SSZ1 STE4 TPS1
    View Details Qiu et al. (2008) ADE16 ADE17

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run RIX7 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ADE17 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..197] PSI-BLAST 11000.0 IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC; AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
    2 View Details [198..378] PSI-BLAST 11000.0 IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC; AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
    3 View Details [379..592] PSI-BLAST 11000.0 IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC; AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • formate dehydrogenase activity
    		•  2.1190774640451 bayes_pls_golite062009
  • catalytic activity
    		•  1.681309422157 bayes_pls_golite062009
  • binding
    		•  1.21541060770936 bayes_pls_golite062009
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity
    		•  1.20917335424321 bayes_pls_golite062009
  • deaminase activity
    		•  1.16510523659661 bayes_pls_golite062009
  • cytidine deaminase activity
    		•  0.870445440530128 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.738911503392967 bayes_pls_golite062009
  • hydroxymethyl-, formyl- and related transferase activity
    		•  0.56822429064158 bayes_pls_golite062009
  • carbon-oxygen lyase activity, acting on phosphates
    		•  0.344740566585736 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.258234666901931 bayes_pls_golite062009
  • electron carrier activity
    		•  0.178707818321223 bayes_pls_golite062009
  • protein binding
    		•  0.072557222523031 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle