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View Structure Prediction Details

Protein: SLX1
Organism: Saccharomyces cerevisiae
Length: 304 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLX1.

Description E-value Query
Range
Subject
Range
SLX1_YEAST - Structure-specific endonuclease subunit SLX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...
SLX1 - Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled...
0.0 [1..304] [1..304]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-88 [4..296] [7..328]
SLX1_SCHPO - Structure-specific endonuclease subunit slx1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
slx1 - structure-specific endonuclease catalytic subunit
9.0E-75 [12..288] [5..237]
GIYD2, GIYD1 - GIY-YIG domain containing 2, GIY-YIG domain containing 1
9.0E-68 [13..292] [13..248]
gi|12852787, gi|... - ref|NP_083696.1| RIKEN cDNA 4833422P03 [Mus musculus], gi|148685468|gb|EDL17415.1| GIY-YIG domain c...
1.0E-40 [13..242] [10..203]
gi|10177383, gi|... - gi|15239808|ref|NP_199135.1| endo/excinuclease amino terminal domain-containing protein [Arabidopsis...
1.0E-20 [14..86] [54..123]

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Predicted Domain #1
Region A:
Residues: [1-167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQKIQQHQF PDFYCCYLLQ SINKRQSFYV GSTPNPVRRL RQHNGKLAVG GAYRTKRDGS  60
   61 RPWEMIMIVR GFPSKIAALQ FEHAWQHGYQ THYIAEKDRV VKHKAGGRTL HHKVALMKLL 120
  121 LKHEFFQRMN LIVEVFNIKA WEVWKQDKFF IERDRFPINI QINENAL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [168-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEPKEKTVDV LMDHSDENLK VVEAVYTKVI ENERNIFETF EKKLTTGVVR CEICEKEIDY  60
   61 TSEEQNLKPF VALCNNKDCG CVNHLKCLHR YFLDDEQLMV GRRNLIPRGG KCPKCDMFCD 120
  121 WTTLVKFSTR MKLAHGK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [180-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHSDENLKVV EAVYTKVIEN ERNIFETFEK KLTTGVVRCE ICEKEIDYTS EEQNLKPFVA  60
   61 LCNNKDCGCV NHLKCLHRYF LDDEQLMVGR RNLIPRGGKC PKCDMFCDWT TLVKFSTRMK 120
  121 LAHGK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.29
Match: 1v87A
Description: Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.56124977034668 bayes_pls_golite062009
protein binding 1.69332800381364 bayes_pls_golite062009
transcription regulator activity 1.34809367817517 bayes_pls_golite062009
nucleic acid binding 1.29443396975472 bayes_pls_golite062009
DNA binding 0.857401028646596 bayes_pls_golite062009
small conjugating protein ligase activity 0.842690858803658 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.740437317894105 bayes_pls_golite062009
transcription factor binding 0.315997284960041 bayes_pls_golite062009
ligase activity 0.204285145398262 bayes_pls_golite062009
catalytic activity 0.168711389690753 bayes_pls_golite062009
transcription factor activity 0.14897188736485 bayes_pls_golite062009
acid-amino acid ligase activity 0.121420290407334 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle