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View Structure Prediction Details

Protein: SLX1
Organism: Saccharomyces cerevisiae
Length: 304 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLX1.

Description E-value Query
Range
Subject
Range
SLX1_YEAST - Structure-specific endonuclease subunit SLX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...
SLX1 - Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled...
0.0 [1..304] [1..304]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-88 [4..296] [7..328]
SLX1_SCHPO - Structure-specific endonuclease subunit slx1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
slx1 - structure-specific endonuclease catalytic subunit
9.0E-75 [12..288] [5..237]
GIYD2, GIYD1 - GIY-YIG domain containing 2, GIY-YIG domain containing 1
9.0E-68 [13..292] [13..248]
gi|12852787, gi|... - ref|NP_083696.1| RIKEN cDNA 4833422P03 [Mus musculus], gi|148685468|gb|EDL17415.1| GIY-YIG domain c...
1.0E-40 [13..242] [10..203]
gi|10177383, gi|... - gi|15239808|ref|NP_199135.1| endo/excinuclease amino terminal domain-containing protein [Arabidopsis...
1.0E-20 [14..86] [54..123]

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Predicted Domain #1
Region A:
Residues: [1-167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQKIQQHQF PDFYCCYLLQ SINKRQSFYV GSTPNPVRRL RQHNGKLAVG GAYRTKRDGS  60
   61 RPWEMIMIVR GFPSKIAALQ FEHAWQHGYQ THYIAEKDRV VKHKAGGRTL HHKVALMKLL 120
  121 LKHEFFQRMN LIVEVFNIKA WEVWKQDKFF IERDRFPINI QINENAL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.432 0.721 DNA repair a.96.1 DNA-glycosylase
View Download 0.307 0.011 DNA-dependent DNA replication a.1.1 Globin-like
View Download 0.314 0.003 DNA-dependent DNA replication c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.337 0.001 DNA-dependent DNA replication d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.467 N/A N/A d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.262 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.256 N/A N/A a.87.1 DBL homology domain (DH-domain)
View Download 0.255 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.227 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.227 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.215 N/A N/A f.1.1 Colicin
View Download 0.210 N/A N/A a.23.2 Diol dehydratase, gamma subunit
View Download 0.200 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #2
Region A:
Residues: [168-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEPKEKTVDV LMDHSDENLK VVEAVYTKVI ENERNIFETF EKKLTTGVVR CEICEKEIDY  60
   61 TSEEQNLKPF VALCNNKDCG CVNHLKCLHR YFLDDEQLMV GRRNLIPRGG KCPKCDMFCD 120
  121 WTTLVKFSTR MKLAHGK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.347 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.551 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.563 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.343 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.334 a.24.9 alpha-catenin/vinculin
View Download 0.306 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.250 a.79.1 Antitermination factor NusB
View Download 0.241 a.24.9 alpha-catenin/vinculin
View Download 0.220 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.218 a.4.1 Homeodomain-like
View Download 0.217 d.2.1 Lysozyme-like
View Download 0.216 a.24.9 alpha-catenin/vinculin
View Download 0.212 a.25.1 Ferritin-like
View Download 0.203 a.60.9 lambda integrase-like, N-terminal domain

Predicted Domain #3
Region A:
Residues: [180-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHSDENLKVV EAVYTKVIEN ERNIFETFEK KLTTGVVRCE ICEKEIDYTS EEQNLKPFVA  60
   61 LCNNKDCGCV NHLKCLHRYF LDDEQLMVGR RNLIPRGGKC PKCDMFCDWT TLVKFSTRMK 120
  121 LAHGK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.29
Match: 1v87A
Description: Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.56124977034668 bayes_pls_golite062009
protein binding 1.69332800381364 bayes_pls_golite062009
transcription regulator activity 1.34809367817517 bayes_pls_golite062009
nucleic acid binding 1.29443396975472 bayes_pls_golite062009
DNA binding 0.857401028646596 bayes_pls_golite062009
small conjugating protein ligase activity 0.842690858803658 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.740437317894105 bayes_pls_golite062009
transcription factor binding 0.315997284960041 bayes_pls_golite062009
ligase activity 0.204285145398262 bayes_pls_golite062009
catalytic activity 0.168711389690753 bayes_pls_golite062009
transcription factor activity 0.14897188736485 bayes_pls_golite062009
acid-amino acid ligase activity 0.121420290407334 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle