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View Structure Prediction Details

Protein: PRP6
Organism: Saccharomyces cerevisiae
Length: 899 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP6.

Description E-value Query
Range
Subject
Range
gi|71895939, gi|... - gi|71895939|ref|NP_001025642.1| MGC97740 protein [Xenopus (Silurana) tropicalis], gi|60550964|gb|AAH...
496.0 [0..2] [895..36]
CG6841-PA - This gene is referred to in FlyBase by the symbol Dmel\CG6841 (CG6841, FBgn0036828). It is a protein...
gi|220950366 - gi|220950366|gb|ACL87726.1| CG6841-PA [synthetic construct]
494.0 [0..3] [896..14]
PRPF6 - PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
491.0 [0..2] [895..4]
gi|55727663 - gi|55727663|emb|CAH90585.1| hypothetical protein [Pongo abelii]
PRP6_PONAB - Pre-mRNA-processing factor 6 OS=Pongo abelii GN=PRPF6 PE=2 SV=1
490.0 [0..2] [895..4]
gi|73992767 - gi|73992767|ref|XP_534481.2| PREDICTED: similar to U5 snRNP-associated 102 kDa protein [Canis famili...
488.0 [0..2] [895..63]
gi|50927247, gi|... - gi|50927247|gb|AAH79686.1| MGC80263 protein [Xenopus laevis], gi|148222496|ref|NP_001087374.1| MGC80...
488.0 [0..2] [895..12]
gi|114683093 - gi|114683093|ref|XP_001152053.1| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]
488.0 [0..2] [895..4]
gi|54641661, gi|... - gi|54641661|gb|EAL30411.1| GA19898-PA [Drosophila pseudoobscura], gi|125977754|ref|XP_001352910.1| G...
487.0 [0..3] [892..14]
PRP6_RAT - Pre-mRNA-processing factor 6 OS=Rattus norvegicus GN=Prpf6 PE=1 SV=1
486.0 [0..2] [895..4]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERPSFLDQE PPAGYVPGIG RGATGFSTKE KQVVSNDDKG RRIPKRYREN LNNHLQSQPK  60
   61 DDEDDEAANV FKTLELKLAQ KKKKRANEKD DDNSVDSSNV KRQFADLKES LAAVTESEWM 120
  121 DIP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [124-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DATDFTRRNK RNRIQEQLNR KTYAAPDSLI PGNVDLNKLT EEREKLLQSQ IDENLAQLTK  60
   61 NASNPIQVNK PNAATDALSY LKDLENDRVN SLSDATLEDL QKMRTILKSY RKADPTNPQG 120
  121 WIASARLEEK ARKFSVAKKI IENGCQECPR S

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 14.34
Match:
Description: No description for 1qqeA was found.

Predicted Domain #3
Region A:
Residues: [275-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDIWLENIRL HESDVHYCKT LVATAINFNP TSPLLWFKAI DLESTTVNKY RVVRKALQEI  60
   61 PRDEGLWKLA VSFEADKAQV IKMLEKATQF IPQSMDLLTA YTNLQSYHNA KMTLNSFRKI 120
  121 LPQEPEIWII STLLEERNNP DIPVDKLVSL LKEGLLELSK NG

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 14.34
Match:
Description: No description for 1qqeA was found.

Predicted Domain #4
Region A:
Residues: [437-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKATLSAWLK RAEALNDAPN SNLTCQAIVY AILEWLRESG EYESELNNVD QILEKMPHSK  60
   61 VQIAVLKKLI QWDPCDTVLW SRLKMATESY HKIEELLAFF QELLFQTKNS DDIRANMREK 120
  121 SPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [560-766]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLMMYVSEYW KAQKGDTRQT LVLIDQIIDF APHNLDLRFF KIKLLGRSLQ LDELRDFFQQ  60
   61 TFSSLEDFKI SGTERLYYKY VNFLRYQDLN EEAIKFLNER CLKSFPICHK FFLQLGQIYH 120
  121 SMGNIEMSRE TYLSGTRLVP NCPLLWVSLS KIDEIDLKNP VRARSILDRG LLKNPDDVLF 180
  181 YIAKIQMEIR LGNLDQAELL VTQALQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [767-899]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPSNALLWVE QIKLFKHGNK SSLKKTIFQD ALRRTQNDHR VLLEIGVSFY AEAQYETSLK  60
   61 WLERALKKCS RYGDTWVWLF RTYARLGKDT VDLYNMFDQC EPTYGPEWIA ASKNVKMQYC 120
  121 TPREILLRLM NDK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.30103
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle